Successful Treatment of Disseminated Disease Due to Highly Resistant Aspergillus calidoustus with a Novel Antifungal Therapy

被引：12

作者：

Camargo, Jose F. ^{[1
]}

Jabr, Ra'ed ^{[1
]}

Anderson, Anthony D. ^{[2
]}

Lekakis, Lazaros ^{[3
]}

Diaz-Paez, Meilin ^{[3
]}

Briski, Laurence M. ^{[4
]}

Raja, Mohammed ^{[1
]}

Morris, Michele, I ^{[1
]}

Komanduri, Krishna, V ^{[3
]}

Pereira, Denise ^{[3
]}

机构：

[1] Univ Miami, Dept Med, Div Infect Dis, Miller Sch Med, Miami, FL 33146 USA

[2] Sylvester Comprehens Canc Ctr, Dept Pharm, Miami, FL USA

[3] Sylvester Comprehens Canc Ctr, Div Transplantat & Cellular Therapy, Miami, FL USA

[4] Univ Miami, Dept Pathol, Miller Sch Med, Miami, FL USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2022年 / 66卷 / 03期

关键词：

Aspergillus calidoustus; APX001; hematopoietic cell transplant; CELL TRANSPLANT RECIPIENTS; INVASIVE FUNGAL-INFECTION; EPIDEMIOLOGY;

D O I：

10.1128/aac.02206-21

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Invasive aspergillosis is the most common invasive mold infection following a hematopoietic cell transplant. Widespread use of antifungal prophylaxis has led to the increasing incidence of cryptic Aspergillus species. Aspergillus calidoustus is one of those emerging species and is notorious for multidrug resistance to antifungals. Here, we report a case of disseminated A. calidoustus infection in a hematopoietic stem cell transplant recipient who was successfully treated with combination therapy that included a novel antifungal. Invasive aspergillosis is the most common invasive mold infection following a hematopoietic cell transplant. Widespread use of antifungal prophylaxis has led to the increasing incidence of cryptic Aspergillus species. Aspergillus calidoustus is one of those emerging species and is notorious for multidrug resistance to antifungals.

引用

页数：5

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