From Channels to Canonical Wnt Signaling: A Pathological Perspective

被引：14

作者：

Muccioli, Silvia ^{[1
]}

Brillo, Valentina ^{[1
]}

Chieregato, Leonardo ^{[1
]}

Leanza, Luigi ^{[1
]}

Checchetto, Vanessa ^{[1
]}

Costa, Roberto ^{[1
]}

机构：

[1] Univ Padua, Dept Biol, I-35122 Padua, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 09期

关键词：

Wnt signaling; ion channels; cancer; metabolic diseases; neurological disorders; BETA-CATENIN; COLORECTAL-CANCER; PROTEIN INTERACTIONS; CELL-PROLIFERATION; GASTRIC-CANCER; ION CHANNELS; MOUSE MODEL; STEM-CELLS; PATHWAY; RECEPTOR;

D O I：

10.3390/ijms22094613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt signaling is an important pathway mainly active during embryonic development and controlling cell proliferation. This regulatory pathway is aberrantly activated in several human diseases. Ion channels are known modulators of several important cellular functions ranging from the tuning of the membrane potential to modulation of intracellular pathways, in particular the influence of ion channels in Wnt signaling regulation has been widely investigated. This review will discuss the known links between ion channels and canonical Wnt signaling, focusing on their possible roles in human metabolic diseases, neurological disorders, and cancer.

引用

页数：14

共 94 条

[91] Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma [J].