Precise Detection of Direct Glomerular Input Duration by the Olfactory Bulb

被引：49

作者：

Li, Anan ^{[1
,2
,3
]}

Gire, David H. ^{[4
,5
]}

Bozza, Thomas ^{[6
]}

Restrepo, Diego ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Cell & Dev Biol, Neurosci Program, Aurora, CO 80045 USA

[2] Univ Colorado, Rocky Mt Taste & Smell Ctr, Aurora, CO 80045 USA

[3] Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China

[4] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[5] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA

[6] Northwestern Univ, Dept Neurobiol, Evanston, IL 60208 USA

来源：

JOURNAL OF NEUROSCIENCE | 2014年 / 34卷 / 48期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

olfactory; puffs; ODOR REPRESENTATIONS; SNIFF; SMELL; NEURONS; CORTEX; BRAIN; MOUSE; DISCRIMINATION; PERCEPTION; RESPONSES;

D O I：

10.1523/JNEUROSCI.3382-14.2014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sensory neuron input to the olfactory bulb (OB) was activated precisely for different durations with blue light in mice expressing channelrhodopsin-2 in olfactory sensory neurons. Behaviorally the mice discriminated differences of 10 ms in duration of direct glomerular activation. In addition, a subset of mitral/tufted cells in the OB of awake mice responded tonically therefore conveying information on stimulus duration. Our study provides evidence that duration of the input to glomeruli not synchronized to sniffing is detected. This potent cue may be used to obtain information on puffs in odor plumes.

引用

页码：16058 / 16064

页数：7

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