Palladium-Catalyzed Aerobic Oxidative Carbonylation of Amines Enables the Synthesis of Unsymmetrical N,N′-Disubstituted Ureas

被引：3

作者：

Zeng, Honglan ^{[1
]}

Du, Hongyan ^{[1
]}

Gong, Xu ^{[1
]}

Zhang, Jie ^{[1
]}

Han, Wei ^{[1
,2
]}

机构：

[1] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Key Lab Appl Photochem, Wenyuan Rd 1, Nanjing 210023, Peoples R China

[2] Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Peoples R China

来源：

SYNLETT | 2021年 / 32卷 / 12期

关键词：

amines; carbonylation; aerobic oxidation; synthetic methods; unsymmetrical ureas; TRANSITION-METAL-FREE; ARYLBORONIC ACIDS; EFFICIENT SYNTHESIS; AMBIENT-PRESSURE; ARYL IODIDES; ONE-POT; CO; ISOCYANATES; AZIDES; MILD;

D O I：

10.1055/a-1500-9673

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ligand-free palladium-catalyzed aerobic oxidative carbonylation of amines for the synthesis of ureas, particular unsymmetrically N,N '-disubstituted ureas, which cannot be accessed by any other palladium-catalyzed oxidative carbonylation of amines to date, is presented. An array of symmetrical and unsymmetrical ureas were straightforwardly synthesized by using inexpensive, readily available, stable, and safe amines with good to excellent yields under a pressure of 1 atm. This novel method employs oxygen as the sole oxidant and offers an attractive alternative to transition-metal-based oxidant systems

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页码：1223 / 1226

页数：4

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