Protein flexibility correlates with degree of hydrogen tunneling in thermophilic and mesophilic alcohol dehydrogenases

被引：77

作者：

Kohen, A

Klinman, JP ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 43期

关键词：

D O I：

10.1021/ja002229k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：10738 / 10739

页数：2

共 19 条

[1] Activated chemistry in the presence of a strongly symmetrically coupled vibration [J].

Antoniou, D ;

Schwartz, SD .

JOURNAL OF CHEMICAL PHYSICS, 1998, 108 (09) :3620-3625

[2] DYNAMIC THEORY OF PROTON TUNNELING TRANSFER RATES IN SOLUTION - GENERAL FORMULATION [J].

BORGIS, D ;

HYNES, JT .

CHEMICAL PHYSICS, 1993, 170 (03) :315-346

[3] Chemical basis for enzyme catalysis [J].

Bruice, TC ;

Benkovic, SJ .

BIOCHEMISTRY, 2000, 39 (21) :6267-6274

[4] HYDROGEN TUNNELING IN ENZYME-REACTIONS [J].

CHA, Y ;

MURRAY, CJ ;

KLINMAN, JP .

SCIENCE, 1989, 243 (4896) :1325-1330

[5] Mechanisms and uses of hydrogen exchange [J].

Englander, SW ;

Sosnick, TR ;

Englander, JJ ;

Mayne, L .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (01) :18-23

[6]

Fersht A. R., 1998, STRUCTURE MECH PROTE

[7] Kinetic studies of the mechanism of carbon-hydrogen bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp 1-IN [J].

Harris, RJ ;

Meskys, R ;

Sutcliffe, MJ ;

Scrutton, NS .

BIOCHEMISTRY, 2000, 39 (06) :1189-1198

[8]

HVIDT A, 1972, J BIOL CHEM, V247, P1530

[9] Hydrogen tunneling in biology [J].

Kohen, A ;

Klinman, JP .

CHEMISTRY & BIOLOGY, 1999, 6 (07) :R191-R198

[10] Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase [J].

Kohen, A ;

Cannio, R ;

Bartolucci, S ;

Klinman, JP .

NATURE, 1999, 399 (6735) :496-499

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