Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review

被引:97
作者
Gao, Jialiang [1 ]
Chen, Guang [1 ,2 ]
He, Haoqiang [1 ,2 ]
Liu, Chao [1 ,2 ]
Xiong, Xingjiang [1 ]
Li, Jun [1 ]
Wang, Jie [1 ]
机构
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiol, Beijing, Peoples R China
[2] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China
关键词
breviscapine; Chinese medicine; ethnopharmacology; herbal medicine; herbal active compounds; TRADITIONAL CHINESE MEDICINE; ISCHEMIA-REPERFUSION INJURY; DRUG-DELIVERY; RAT PLASMA; SCUTELLARIN; CARDIOMYOCYTES; INHIBITION; ATHEROSCLEROSIS; ENDOTHELIUM; MYOCARDITIS;
D O I
10.3389/fphar.2017.00289
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction. In addition, several clinical studies have reported that breviscapine could be used in conjunction with Western medicine for cardiovascular diseases (CVDs) including coronary heart disease, myocardial infarction, hypertension, atrial fibrillation, hyperlipidaemia, viral myocarditis, chronic heart failure, and pulmonary heart disease. However, the protective effects of breviscapine on CVDs based on experimental studies along with its underlying mechanisms have not been reviewed systematically. This paper reviewed the underlying pharmacological mechanisms in the cardioprotective effects of breviscapine and elucidated its clinical applications.
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页数:13
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