Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship

被引:18
作者
Briu, Lina-Marie [1 ]
Maric, Chrystelle [1 ]
Cadoret, Jean-Charles [1 ]
机构
[1] Univ Paris, CNRS, Inst Jacques Monod, F-75006 Paris, France
关键词
replication timing; replication stress; genomic instability; cancers; DNA-POLYMERASE-THETA; TOPOLOGICALLY ASSOCIATING DOMAINS; BETA-GLOBIN LOCUS; BREAST-CANCER; CHROMOSOME CONDENSATION; NUCLEAR-ORGANIZATION; SPATIAL-ORGANIZATION; HISTONE ACETYLATION; DELAYED REPLICATION; TOPOISOMERASE-II;
D O I
10.3390/ijms22094764
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The replication-timing program constitutes a key element of the organization and coordination of numerous nuclear processes in eukaryotes. This program is established at a crucial moment in the cell cycle and occurs simultaneously with the organization of the genome, thus indicating the vital significance of this process. With recent technological achievements of high-throughput approaches, a very strong link has been confirmed between replication timing, transcriptional activity, the epigenetic and mutational landscape, and the 3D organization of the genome. There is also a clear relationship between replication stress, replication timing, and genomic instability, but the extent to which they are mutually linked to each other is unclear. Recent evidence has shown that replication timing is affected in cancer cells, although the cause and consequence of this effect remain unknown. However, in-depth studies remain to be performed to characterize the molecular mechanisms of replication-timing regulation and clearly identify different cis- and trans-acting factors. The results of these studies will potentially facilitate the discovery of new therapeutic pathways, particularly for personalized medicine, or new biomarkers. This review focuses on the complex relationship between replication timing, replication stress, and genomic instability.
引用
收藏
页数:26
相关论文
共 184 条
[1]   Negative supercoil at gene boundaries modulates gene topology [J].
Achar, Yathish Jagadheesh ;
Adhil, Mohamood ;
Choudhary, Ramveer ;
Gilbert, Nick ;
Foiani, Marco .
NATURE, 2020, 577 (7792) :701-+
[2]   The evolution of the temporal program of genome replication [J].
Agier, Nicolas ;
Delmas, Stephane ;
Zhang, Qing ;
Fleiss, Aubin ;
Jaszczyszyn, Yan ;
van Dijk, Erwin ;
Thermes, Claude ;
Weigt, Martin ;
Cosentino-Lagomarsino, Marco ;
Fischer, Gilles .
NATURE COMMUNICATIONS, 2018, 9
[3]   DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients [J].
Allera-Moreau, C. ;
Rouquette, I. ;
Lepage, B. ;
Oumouhou, N. ;
Walschaerts, M. ;
Leconte, E. ;
Schilling, V. ;
Gordien, K. ;
Brouchet, L. ;
Delisle, M. B. ;
Mazieres, J. ;
Hoffmann, J. S. ;
Pasero, P. ;
Cazaux, C. .
ONCOGENESIS, 2012, 1 :e30-e30
[4]   Chromatin conformation regulates the coordination between DNA replication and transcription [J].
Almeida, Ricardo ;
Miguel Fernandez-Justel, Jose ;
Santa-Maria, Cristina ;
Cadoret, Jean-Charles ;
Cano-Aroca, Laura ;
Lombrana, Rodrigo ;
Herranz, Gonzalo ;
Agresti, Alessandra ;
Gomez, Maria .
NATURE COMMUNICATIONS, 2018, 9
[5]   Replication in hydroxyurea: It's a matter of time [J].
Alvino, Gina M. ;
Collingwood, David ;
Murphy, John M. ;
Delrow, Jeffrey ;
Brewer, Bonita J. ;
Raghuraman, M. K. .
MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (18) :6396-6406
[6]   Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication [J].
Ardeljan, Daniel ;
Steranka, Jared P. ;
Liu, Chunhong ;
Li, Zhi ;
Taylor, Martin S. ;
Payer, Lindsay M. ;
Gorbounov, Mikhail ;
Sarnecki, Jacob S. ;
Deshpande, Vikram ;
Hruban, Ralph H. ;
Boeke, Jef D. ;
Feny, David ;
Wu, Pei-Hsun ;
Smogorzewska, Agata ;
Holland, Andrew J. ;
Burns, Kathleen H. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2020, 27 (02) :168-+
[7]   Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction [J].
Bacolla, Albino ;
Ye, Zu ;
Ahmed, Zamal ;
Tainer, John A. .
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2019, 147 :47-61
[8]   Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine [J].
Balachander, Sathya ;
Gombolay, Alli L. ;
Yang, Taehwan ;
Xu, Penghao ;
Newnam, Gary ;
Keskin, Havva ;
El-Sayed, Waleed M. M. ;
Bryksin, Anton, V ;
Tao, Sijia ;
Bowen, Nicole E. ;
Schinazi, Raymond F. ;
Kim, Baek ;
Koh, Kyung Duk ;
Vannberg, Fredrik O. ;
Storici, Francesca .
NATURE COMMUNICATIONS, 2020, 11 (01)
[9]   Identification of Early Replicating Fragile Sites that Contribute to Genome Instability [J].
Barlow, Jacqueline H. ;
Faryabi, Robert B. ;
Callen, Elsa ;
Wong, Nancy ;
Malhowski, Amy ;
Chen, Hua Tang ;
Gutierrez-Cruz, Gustavo ;
Sun, Hong-Wei ;
McKinnon, Peter ;
Wright, George ;
Casellas, Rafael ;
Robbiani, Davide F. ;
Staudt, Louis ;
Fernandez-Capetillo, Oscar ;
Nussenzweig, Andre .
CELL, 2013, 152 (03) :620-632
[10]   Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption [J].
Beck, Halfdan ;
Nahse-Kumpf, Viola ;
Larsen, Marie Sofie Yoo ;
O'Hanlon, Karen A. ;
Patzke, Sebastian ;
Holmberg, Christian ;
Mejlvang, Jakob ;
Groth, Anja ;
Nielsen, Olaf ;
Syljuasen, Randi G. ;
Sorensen, Claus Storgaard .
MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (20) :4226-4236