The Effect of Media Composition, pH, and Formulation Excipients on the In Vitro Lipolysis of Self-Emulsifying Drug Delivery Systems (SEDDS)

被引：9
|
作者：
Ali, Hazem [1 ]
Siddiqui, Akhtar [1 ]
Nazzal, Sami [1 ]
机构：
[1] Univ Louisiana Monroe, Coll Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71209 USA
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2010年 / 31卷 / 02期
关键词：
Digestion; emulsion; fatty acids; lipolysis; SEDDS; WATER-SOLUBLE DRUGS; SOLUBILIZATION BEHAVIOR; ORAL BIOAVAILABILITY; LIPID FORMULATIONS; PANCREATIC LIPASE; LIPOPHILIC DRUGS; VIVO PERFORMANCE; FAT DIGESTION; DISSOLUTION; ABSORPTION;
D O I：
10.1080/01932690903110566
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The objective of the present work was to investigate the effects of pH, ions, and excipients on the in vitro lipolysis of self-emulsifying drug delivery systems (SEDDS). Studies were performed in bio-relevant media using a pH stat autotitrator for analysis. The results demonstrated that alkaline media were essential for lipolysis, which was enhanced by divalent CaCl2 ions and medium chain glycerides. Monovalent NaCl and the hydrophile-lipophile balance (HLB) of the surfactant had insignificant effect on lipolysis. Consequently, it was concluded that the activity of lipase, at an optimum pH of 6.5, is the predominant factors for digestion of SEDDS.
引用
收藏
页码：226 / 232
页数：7
相关论文
共 50 条
  • [31] A Rundown Through Various Methods Used in the Formulation of Solid Self-Emulsifying Drug Delivery Systems (S-SEDDS)
    Almeida, Sharel Rency D.
    Tippavajhala, Vamshi Krishna
    AAPS PHARMSCITECH, 2019, 20 (08)
  • [32] Impact of Porous Excipients on the Manufacturability and Product Performance of Solid Self-Emulsifying Drug Delivery Systems
    Beringhs, Andre O'Reilly
    Minatovicz, Bruna Cristina
    Zhang, Geoff G. Z.
    Chaudhuri, Bodhisattwa
    Lu, Xiuling
    AAPS PHARMSCITECH, 2018, 19 (07): : 3298 - 3310
  • [33] Nonlinear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: In Vivo and In Vitro Studies
    Alqahtani, Saeed
    Alayoubi, Alaadin
    Nazzal, Sami
    Sylvester, Paul W.
    Kaddoumi, Amal
    AAPS JOURNAL, 2013, 15 (03): : 684 - 695
  • [34] Solidification of self-emulsifying drug delivery systems (SEDDS): Impact on storage stability of a therapeutic protein
    Friedl, Julian David
    Joergensen, Arne Matteo
    Bao Le-Vinh
    Braun, Doris Elfriede
    Tribus, Martina
    Bernkop-Schnuerch, Andreas
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2021, 584 : 684 - 697
  • [35] Enhanced dissolution of celecoxib by supersaturating self-emulsifying drug delivery system (S-SEDDS) formulation
    Song, Woo Heon
    Park, Jong Hyeok
    Yeom, Dong Woo
    Ahn, Byeong Kil
    Lee, Kyung Min
    Lee, Sang Gon
    Woo, Hye Seung
    Choi, Young Wook
    ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (01) : 69 - 78
  • [36] Imine bond formation as a tool for incorporation of amikacin in self-emulsifying drug delivery systems (SEDDS)
    Dizdarevic, Aida
    Maric, Melani
    Shahzadi, Iram
    Efiana, Nuri Ari
    Matuszczak, Barbara
    Bernkop-Schnurch, Andreas
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2021, 162 : 82 - 91
  • [37] Integrated in silico formulation design of self-emulsifying drug delivery systems
    Gao, Haoshi
    Jia, Haoyue
    Dong, Jie
    Yang, Xinggang
    Li, Haifeng
    Ouyang, Defang
    ACTA PHARMACEUTICA SINICA B, 2021, 11 (11) : 3585 - 3594
  • [38] Development of self-emulsifying drug delivery systems (SEDDS) for ciprofloxacin with improved mucus permeating properties
    Zaichik, Sergey
    Steinbring, Christian
    Menzel, Claudia
    Knabl, Ludwig
    Orth-Hoeller, Dorothea
    Ellemunter, Helmut
    Niedermayr, Katharina
    Bernkop-Schnuerch, Andreas
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 547 (1-2) : 282 - 290
  • [39] Formulation and Evaluation of Self-Emulsifying Drug Delivery Systems of Rosuvastatin Calcium
    Desavathu, Madhuri
    Rani, A. Prameela
    ASIAN JOURNAL OF PHARMACEUTICS, 2021, 15 (01) : 27 - 32
  • [40] Development and Optimization of Self-emulsifying Drug Delivery Systems (SEDDS) for Enhanced Dissolution and Permeability of Rosuvastatin
    Karasulu, H. Y.
    Gundogdu, E.
    Turgay, T.
    Turk, U. O.
    Apaydin, S.
    Simsir, I. Yildirim
    Yilmaz, C.
    Karasulu, E.
    CURRENT DRUG DELIVERY, 2016, 13 (03) : 362 - 370
12345