The Effect of Media Composition, pH, and Formulation Excipients on the In Vitro Lipolysis of Self-Emulsifying Drug Delivery Systems (SEDDS)

被引：9

作者：

Ali, Hazem ^{[1
]}

Siddiqui, Akhtar ^{[1
]}

Nazzal, Sami ^{[1
]}

机构：

[1] Univ Louisiana Monroe, Coll Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71209 USA

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2010年 / 31卷 / 02期

关键词：

Digestion; emulsion; fatty acids; lipolysis; SEDDS; WATER-SOLUBLE DRUGS; SOLUBILIZATION BEHAVIOR; ORAL BIOAVAILABILITY; LIPID FORMULATIONS; PANCREATIC LIPASE; LIPOPHILIC DRUGS; VIVO PERFORMANCE; FAT DIGESTION; DISSOLUTION; ABSORPTION;

D O I：

10.1080/01932690903110566

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The objective of the present work was to investigate the effects of pH, ions, and excipients on the in vitro lipolysis of self-emulsifying drug delivery systems (SEDDS). Studies were performed in bio-relevant media using a pH stat autotitrator for analysis. The results demonstrated that alkaline media were essential for lipolysis, which was enhanced by divalent CaCl2 ions and medium chain glycerides. Monovalent NaCl and the hydrophile-lipophile balance (HLB) of the surfactant had insignificant effect on lipolysis. Consequently, it was concluded that the activity of lipase, at an optimum pH of 6.5, is the predominant factors for digestion of SEDDS.

引用

页码：226 / 232

页数：7

共 50 条

[21] Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10:: formulation development and bioavailability assessment
Kommuru, TR
Gurley, B
Khan, MA
Reddy, IK
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 212 (02) : 233 - 246
[22] Monoacyl phosphatidylcholine inhibits the formation of lipid multilamellar structures during in vitro lipolysis of self-emulsifying drug delivery systems
Thuy Tran
Siqueira, Scheyla D. V. S.
Amenitsch, Heinz
Rades, Thomas
Mullertz, Anette
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 108 : 62 - 70
[23] In vitro evaluation of a self-emulsifying drug delivery system (SEDDS) for nasal administration of dimenhydrinate
Leichner, Christina
Baus, Randi Angela
Jelkmann, Max
Plautz, Melanie
Barthelmes, Jan
Duennhaupt, Sarah
Bernkop-Schnuerch, Andreas
DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2019, 9 (05) : 945 - 955
[24] Insights into Novel Excipients of Self-Emulsifying Drug Delivery Systems and Their Significance: An Updated Review
Rani, Earle Radha
Radha, G., V
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2021, 38 (02): : 27 - 74
[25] Oral self-emulsifying drug delivery systems, from biopharmaceutical to technical formulation aspects
Kuentz, M.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2011, 21 (01) : 17 - 26
[26] Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol
Aloisio, Carolina
Soledad Bueno, Maria
Ponce Ponte, Micaela
Paredes, Alejandro
Daniel Palma, Santiago
Longhi, Marcela
THERAPEUTIC DELIVERY, 2019, 10 (10) : 627 - 642
[27] Self-emulsifying drug delivery systems with atorvastatin adsorbed on solid carriers: formulation and in vitro drug release studies
Snela, Agnieszka
Jadach, Barbara
Froelich, Anna
Skotnicki, Marcin
Milczewska, Kasylda
Rojewska, Monika
Voelkel, Adam
Prochaska, Krystyna
Lulek, Janina
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2019, 577 : 281 - 290
[28] Preparation and Evaluation of Self-emulsifying Drug Delivery System (SEDDS) of Cepharanthine
Pan Gao
Zhujun Jiang
Qiao Luo
Chengqiao Mu
Mengsuo Cui
Xinggang Yang
AAPS PharmSciTech, 22
[29] Preparation and Evaluation of Self-emulsifying Drug Delivery System (SEDDS) of Cepharanthine
Yang, Xinggang
Gao, Pan
Jiang, Zhujun
Luo, Qiao
Mu, Chengqiao
Cui, Mengsuo
AAPS PHARMSCITECH, 2021, 22 (07)
[30] Development and in vitro characterization of self-emulsifying drug delivery system (SEDDS) for oral opioid peptide delivery
Zupancic, Ozbej
Rohrer, Julia
Hung Thanh Lam
Griessinger, Julia Anita
Bernkop-Schnurch, Andreas
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2017, 43 (10) : 1694 - 1702

← 1 2 3 4 5 →