Assessment of detection methods in trace analysis by means of a statistically based in-house validation concept

被引：58

作者：

Jülicher, B

Gowik, P

Uhlig, S

机构：

[1] Fed Inst Hlth Protect Consumers & Vet Med, EU Reference Lab Residues Vet Drugs, Div Anim Drug Registrat Resid Contr & Feed Addit, D-12277 Berlin, Germany

[2] Free Univ Berlin, Inst Stat & Econometr, D-14195 Berlin, Germany

来源：

ANALYST | 1998年 / 123卷 / 02期

关键词：

validation; calibration; variance component model; power function; uncertainty; trace analysis; residue analysis; limit of detection; critical concentration;

D O I：

10.1039/a707281c

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A matrix-considering in-house validation concept for analytical methods is presented which takes into account the uncertainty due to matrix- and time-induced deviations, It is based on a variance component model for univariate quantitative measurement data that can be adapted to both screening and confirmation methods and to both zero-tolerance and threshold decisions, The model allows the calculation of critical concentrations for given a-errors and the calculation of the corresponding power function to evaluate the performance of an analytical method. The model is applied to a real-life validation experiment.

引用

页码：173 / 179

页数：7