The Vps13 Family of Lipid Transporters and Its Role at Membrane Contact Sites

被引：69

作者：

Dziurdzik, Samantha Katarzyna ^{[1
,2
]}

Conibear, Elizabeth ^{[1
,2
]}

机构：

[1] Univ British Columbia, British Columbia Childrens Hosp, Ctr Mol Med & Therapeut, Res Inst, Vancouver, BC V5Z 4H4, Canada

[2] Univ British Columbia, Dept Med Genet, Fac Med, Vancouver, BC V5Z 4H4, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 06期

基金：

加拿大健康研究院;

关键词：

Vps13; Atg2; membrane contact sites; lipid transport; yeast model; chorea acanthocytosis; Cohen syndrome; Parkinson’ s disease; ataxia; SYNDROME-ASSOCIATED PROTEIN; COHEN-SYNDROME; PIECEMEAL MICROAUTOPHAGY; PHAGOSOMAL PROTEOME; STRUCTURAL BASIS; BINDING-SITE; ER; PHOSPHATIDYLSERINE; MUTATIONS; DOMAINS;

D O I：

10.3390/ijms22062905

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conserved VPS13 proteins constitute a new family of lipid transporters at membrane contact sites. These large proteins are suspected to bridge membranes and form a direct channel for lipid transport between organelles. Mutations in the 4 human homologs (VPS13A-D) are associated with a number of neurological disorders, but little is known about their precise functions or the relevant contact sites affected in disease. In contrast, yeast has a single Vps13 protein which is recruited to multiple organelles and contact sites. The yeast model system has proved useful for studying the function of Vps13 at different organelles and identifying the localization determinants responsible for its membrane targeting. In this review we describe recent advances in our understanding of VPS13 proteins with a focus on yeast research.

引用

页码：1 / 17

页数：16

共 93 条

[1] De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy [J].

Andrejeva, Gabriela ;

Gowan, Sharon ;

Lin, Gigin ;

Te Fong, Anne-Christine L. F. Wong ;

Shamsaei, Elham ;

Parkes, Harry G. ;

Mui, James ;

Raynaud, Florence I. ;

Asad, Yasmin ;

Vizcay-Barrena, Gema ;

Nikitorowicz-Buniak, Joanna ;

Valenti, Melanie ;

Howell, Louise ;

Fleck, Roland A. ;

Martin, Lesley-Ann ;

Kirkin, Vladimir ;

Leach, Martin O. ;

Chung, Yuen-Li .

AUTOPHAGY, 2020, 16 (06) :1044-1060

[2] ISOLATION OF YEAST MUTANTS DEFECTIVE IN PROTEIN TARGETING TO THE VACUOLE [J].

BANKAITIS, VA ;

JOHNSON, LM ;

EMR, SD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (23) :9075-9079

[3] Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites [J].

Bean, Bjorn D. M. ;

Dziurdzik, Samantha K. ;

Kolehmainen, Kathleen L. ;

Fowler, Claire M. S. ;

Kwong, Waldan K. ;

Grad, Leslie I. ;

Davey, Michael ;

Schluter, Cayetana ;

Conibear, Elizabeth .

JOURNAL OF CELL BIOLOGY, 2018, 217 (10) :3593-3607

[4] The PH superfold: a structural scaffold for multiple functions [J].

Blomberg, N ;

Baraldi, E ;

Nilges, M ;

Saraste, M .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (11) :441-445

[5] SNX14 mutations affect endoplasmic reticulum-associated neutral lipid metabolism in autosomal recessive spinocerebellar ataxia 20 [J].

Bryant, Dale ;

Liu, Yang ;

Datta, Sanchari ;

Hariri, Hanaa ;

Seda, Marian ;

Anderson, Glenn ;

Peskett, Emma ;

Demetriou, Charalambos ;

Sousa, Sergio ;

Jenkins, Dagan ;

Clayton, Peter ;

Bitner-Glindzicz, Maria ;

Moore, Gudrun E. ;

Henne, W. Mike ;

Stanier, Philip .

HUMAN MOLECULAR GENETICS, 2018, 27 (11) :1927-1940

[6] Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy [J].

Chen, Shuliang ;

Mari, Muriel ;

Parashar, Smriti ;

Liu, Dongmei ;

Cui, Yixian ;

Reggiori, Fulvio ;

Novick, Peter J. ;

Ferro-Novick, Susan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (31) :18530-18539

[7] Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex [J].

Chowdhury, Saikat ;

Otomo, Chinatsu ;

Leitner, Alexander ;

Ohashi, Kazuto ;

Aebersold, Ruedi ;

Lander, Gabriel C. ;

Otomo, Takanori .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (42) :E9792-E9801

[8] Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking [J].

Da Costa, Romain ;

Bordessoules, Morgane ;

Guilleman, Magali ;

Carmignac, Virginie ;

Lhussiez, Vincent ;

Courot, Hortense ;

Bataille, Amandine ;

Chlemaire, Amandine ;

Bruno, Celine ;

Fauque, Patricia ;

Thauvin, Christel ;

Faivre, Laurence ;

Duplomb, Laurence .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2020, 77 (03) :511-529

[9] Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts [J].

Datta, Sanchari ;

Liu, Yang ;

Hariri, Hanaa ;

Bowerman, Jade ;

Henne, W. Mike .

JOURNAL OF CELL BIOLOGY, 2019, 218 (04) :1335-1351

[10] The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion [J].

De, Mithu ;

Oleskie, Austin N. ;

Ayyash, Mariam ;

Dutta, Somnath ;

Mancour, Liliya ;

Abazeed, Mohamed E. ;

Brace, Eddy J. ;

Skiniotis, Georgios ;

Fuller, Robert S. .

JOURNAL OF CELL BIOLOGY, 2017, 216 (02) :425-439

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