Systemic Therapies for Advanced Melanoma

被引：47

作者：

Bomar, Leonora ^{[1
]}

Senithilnathan, Aditi ^{[1
]}

Ahn, Christine ^{[1
]}

机构：

[1] Wake Forest Sch Med, Dept Dermatol, Winston Salem, NC USA

来源：

DERMATOLOGIC CLINICS | 2019年 / 37卷 / 04期

关键词：

Melanoma; Metastatic; Advanced; BRAF inhibitors; MEK inhibitors; Anti-PD1; agents; Ipilimumab; Chemotherapy; CUTANEOUS ADVERSE EVENTS; RANDOMIZED PHASE-III; RESECTED STAGE-III; METASTATIC MELANOMA; BRAF INHIBITORS; OPEN-LABEL; DOSE INTERFERON-ALPHA-2B; IMPROVED SURVIVAL; ADJUVANT THERAPY; MEK INHIBITORS;

D O I：

10.1016/j.det.2019.05.001

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The incidence of metastatic melanoma continues to increase each decade. Although surgical treatment is often curative for localized stage I and stage II disease, the median survival for patients with distant metastases is less than 1 year. The last 2 decades have witnessed a breakthrough in therapeutic options with the development of immune checkpoint inhibitors, small molecule targeted therapy, and oncolytic viral therapy. This article provides an overview of the treatment options available for advanced melanoma, including chemotherapy, targeted therapy, immunotherapy, interleukin-2, and oncolytic viral agents.

引用

页码：409 / +

页数：16

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