Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition

被引：215

作者：

Dossus, Laure ^{[1
]}

Allen, Naomi ^{[2
]}

Kaaks, Rudolf ^{[1
]}

Bakken, Kjersti ^{[3
]}

Lund, Eiliv ^{[3
]}

Tjonneland, Anne ^{[4
]}

Olsen, Anja ^{[4
]}

Overvad, Kim ^{[5
]}

Clavel-Chapelon, Francoise ^{[6
]}

Fournier, Agnes ^{[6
]}

Chabbert-Buffet, Nathalie ^{[7
]}

Boeing, Heiner ^{[8
]}

Schuetze, Madlen ^{[8
]}

Trichopoulou, Antonia ^{[9
]}

Trichopoulos, Dimitrios ^{[10
]}

Lagiou, Pagona ^{[9
]}

Palli, Domenico ^{[11
]}

Krogh, Vittorio ^{[12
]}

Tumino, Rosario ^{[13
,14
]}

Vineis, Paolo ^{[15
]}

Mattiello, Amalia ^{[16
]}

Bueno-de-Mesquita, H. Bas ^{[17
]}

Onland-Moret, N. Charlotte ^{[18
,19
]}

Peeters, Petra H. M. ^{[18
]}

Dumeaux, Vanessa ^{[3
,20
]}

Redondo, Maria-Luisa ^{[21
]}

Duell, Eric ^{[22
]}

Sanchez-Cantalejo, Emilio ^{[23
]}

Arriola, Larraitz ^{[24
]}

Chirlaque, Maria-Dolores ^{[25
]}

Ardanaz, Eva ^{[26
]}

Manjer, Jonas ^{[27
]}

Borgquist, Signe ^{[28
]}

Lukanova, Annie ^{[1
,29
]}

Lundin, Eva ^{[30
]}

Khaw, Kay-Tee ^{[31
]}

Wareham, Nicholas ^{[32
]}

Key, Tim ^{[2
]}

Chajes, Veronique ^{[33
,34
]}

Rinaldi, Sabina ^{[33
]}

Slimani, Nadia ^{[33
]}

Mouw, Traci ^{[15
]}

Gallo, Valentina ^{[15
]}

Riboli, Elio ^{[15
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany

[2] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[3] Univ Tromso, Inst Community Med, Tromso, Norway

[4] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[5] Aarhus Univ, Dept Clin Epidemiol, Aalborg, Denmark

[6] Inst Gustave Roussy, INSERM, F-94805 Villejuif, France

[7] APHP Hosp, Obstet Gynecol & Reprod Med Unit, Tenon, France

[8] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[9] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[10] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[11] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[12] Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Nutr Epidemiol Unit, Milan, Italy

[13] Civile MP Arezzo Hosp, Dept Oncol, Histopathol Unit, Ragusa, Italy

[14] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[15] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

[16] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[17] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[18] UMC Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[19] UMC Utrecht, Dept Med Genet DBG, Complex Genet Sect, Utrecht, Netherlands

[20] Rikshosp Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Genet, Oslo, Norway

[21] Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[22] Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[23] Andalusian Sch Publ Hlth, Granada, Spain

[24] Basque Govt, Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[25] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[26] Publ Hlth Inst Navarra, Pamplona, Spain

[27] Lund Univ, Dept Surg, Malmo Univ Hosp, Lund, Sweden

[28] Lund Univ, Dept Oncol, Univ Lund Hosp, Lund, Sweden

[29] Umea Univ, Dept Publ Hlth & Clin Med Nutr Res, Umea, Sweden

[30] Umea Univ, Dept Med Biosci Pathol, Umea, Sweden

[31] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[32] MRC Epidemiol Unit, Cambridge, England

[33] Int Agcy Res Canc, F-69372 Lyon, France

[34] Inst Gustave Roussy, CNRS, FRE 2939, Villejuif, France

来源：

INTERNATIONAL JOURNAL OF CANCER | 2010年 / 127卷 / 02期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

endometrial cancer; parity; menarche; menopause; oral contraceptive; PHYSICAL-ACTIVITY; WOMEN; POPULATION; BREAST; AGE; OVARIAN; CORPUS; HEALTH;

D O I：

10.1002/ijc.25050

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity and a shorter time since last full-term pregnancy (FTP). No association was observed for duration of breast feeding after adjustment for number of FTP or for abortion (spontaneous or induced). After mutual adjustment, late age at menarche, early age at menopause and duration of OC use showed similar risk reductions of 7-8% per year of menstrual life, whereas the decreased risk associated with cumulative duration of FTPs was stronger (22% per year). In conclusion, our findings confirmed a reduction in risk of endometrial cancer with factors associated with a lower cumulative exposure to estrogen and/or higher exposure to progesterone, such as increasing number of FTPs and shorter menstrual lifespan and, therefore, support an important role of hormonal mechanisms in endometrial carcinogenesis.

引用

页码：442 / 451

页数：10

共 29 条

[1] IS THE RISK OF CANCER OF THE CORPUS-UTERI REDUCED BY A RECENT PREGNANCY - A PROSPECTIVE-STUDY OF 765,756 NORWEGIAN WOMEN [J].

ALBREKTSEN, G ;

HEUCH, I ;

TRETLI, S ;

KVALE, G .

INTERNATIONAL JOURNAL OF CANCER, 1995, 61 (04) :485-490

[2] A cross-sectional analysis of physical activity and obesity indicators in European participants of the EPIC-PANACEA study [J].

Besson, H. ;

Ekelund, U. ;

Luan, J. ;

May, A. M. ;

Sharp, S. ;

Travier, N. ;

Agudo, A. ;

Slimani, N. ;

Rinaldi, S. ;

Jenab, M. ;

Norat, T. ;

Mouw, T. ;

Rohrmann, S. ;

Kaaks, R. ;

Bergmann, M. ;

Boeing, H. ;

Clavel-Chapelon, F. ;

Boutron-Ruault, M. C. ;

Overvad, K. ;

Andreasen, E. L. ;

Johnsen, N. Fons ;

Halkjaer, J. ;

Gonzalez, C. ;

Rodriguez, L. ;

Sanchez, M. J. ;

Arriola, L. ;

Barricarte, A. ;

Navarro, C. ;

Key, T. J. ;

Spencer, E. A. ;

Orfanos, P. ;

Naska, A. ;

Trichopoulou, A. ;

Manjer, J. ;

Wirfaelt, E. ;

Lund, E. ;

Palli, D. ;

Agnoli, C. ;

Vineis, P. ;

Panico, S. ;

Tumino, R. ;

Bueno-de-Mesquita, H. B. ;

van den Berg, S. W. ;

Odysseos, A. D. ;

Riboli, E. ;

Wareham, N. J. ;

Peeters, P. H. .

INTERNATIONAL JOURNAL OF OBESITY, 2009, 33 (04) :497-506

[3] Reproductive risk factors for endometrial cancer among Polish women [J].

Brinton, L. A. ;

Sakoda, L. C. ;

Lissowska, J. ;

Sherman, M. E. ;

Chatterjee, N. ;

Peplonska, B. ;

Szeszenia-Dabrowska, N. ;

Zatonski, W. ;

Garcia-Closas, M. .

BRITISH JOURNAL OF CANCER, 2007, 96 (09) :1450-1456

[4] REPRODUCTIVE, MENSTRUAL, AND MEDICAL RISK-FACTORS FOR ENDOMETRIAL CANCER - RESULTS FROM A CASE-CONTROL STUDY [J].

BRINTON, LA ;

BERMAN, ML ;

MORTEL, R ;

TWIGGS, LB ;

BARRETT, RJ ;

WILBANKS, GD ;

LANNOM, L ;

HOOVER, RN .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 167 (05) :1317-1325

[5] Past oral contraceptive and hormone therapy use and endogenous hormone concentrations in postmenopausal women [J].

Chan, Mei-Fen ;

Dowsett, Mitch ;

Folkerd, Elizabeth ;

Wareham, Nicholas ;

Luben, Robert ;

Welch, Ailsa ;

Bingham, Sheila ;

Khaw, Kay-Tee .

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2008, 15 (02) :332-339

[6] Hormonal interactions in endometrial cancer [J].

Emons, G ;

Fleckenstein, G ;

Hinney, B ;

Huschmand, A ;

Heyl, W .

[7] Physical activity of subjects aged 50-64 years involved in the European Prospective Investigation into Cancer and Nutrition (EPIC) [J].

Haftenberger, M ;

Schuit, AJ ;

Tormo, N ;

Boeing, H ;

Wareham, N ;

Bueno-de-Mesquita, HB ;

Kumle, M ;

Hjartåker, A ;

Chirlaque, MD ;

Ardanaz, E ;

Andren, C ;

Lindahl, B ;

Peeters, PHM ;

Allen, NE ;

Overvad, K ;

Tjonneland, A ;

Clavel-Chapelon, F ;

Linseisen, J ;

Bergmann, MM ;

Trichopoulou, A ;

Lagiou, P ;

Salvini, S ;

Panico, S ;

Riboli, E ;

Ferrari, P ;

Slimani, N .

PUBLIC HEALTH NUTRITION, 2002, 5 (6B) :1163-1177

[8] Endometrial cancer:: Population attributable risks from reproductive, familial and socioeconomic factors [J].

Hemminki, K ;

Bermejo, JL ;

Granström, C .

EUROPEAN JOURNAL OF CANCER, 2005, 41 (14) :2155-2159

[9] Modeling effects of age at and time since delivery on subsequent risk of cancer [J].

Heuch, I ;

Albrektsen, G ;

Kvåle, G .

EPIDEMIOLOGY, 1999, 10 (06) :739-746

[10] Grand multiparity and incidence of endometrial cancer:: a population-based study in Finland [J].

Hinkula, M ;

Pukkala, E ;

Kyyrönen, P ;

Kauppila, A .

INTERNATIONAL JOURNAL OF CANCER, 2002, 98 (06) :912-915

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