Protection of the C(7) and C(10) hydroxyl groups in 10-deacetyl baccatin III

被引：53

作者：

Holton, RA ^{[1
]}

Zhang, ZM ^{[1
]}

Clarke, PA ^{[1
]}

Nadizadeh, H ^{[1
]}

Procter, DJ ^{[1
]}

机构：

[1] Florida State Univ, Ditlmer Lab Chem, Tallahassee, FL 32306 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 19期

关键词：

acylation; lanthanides; protecting groups; taxoid;

D O I：

10.1016/S0040-4039(98)00424-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New protocols for the selective protection of the C(7) and C(10) hydroxyl groups of 10-deacetyl baccatin III are described, leading to more efficient semisyntheses of taxol and taxol analogs. The C(10) hydroxyl group of 10-DAB can be highly selectively acylated or silylated, and subsequent selective protection of the C(7) hydroxyl group then becomes straightforward. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2883 / 2886

页数：4

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