Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid

被引：11
作者：
Gonzalez-Vargas, Camilo [1 ]
Serrano, Nuria [2 ]
Arino, Cristina [2 ]
Salazar, Ricardo [1 ]
Esteban, Miquel [2 ]
Manuel Diaz-Cruz, Jose [2 ]
机构：
[1] Univ Santiago Chile, Fac Quim & Biol, Dept Quim Mat, Lab Electroquim Medio Ambiente,USACh, Casilla 40,Correo 33, Santiago 717835, Chile
[2] Univ Barcelona, Fac Quim, Dept Engn Quim & Quim Analit, Marti & Franques 1-11, E-08028 Barcelona, Spain
来源：
CHEMOSENSORS | 2017年 / 5卷 / 03期
关键词：
glutamic acid-modified screen-printed electrode; voltammetry; electropolymerization; electrografting; hydrochlorothiazide determination; GLASSY-CARBON ELECTRODE; CHEMICALLY-MODIFIED ELECTRODE; ETHER-MODIFIED ELECTRODES; DOPED DIAMOND ELECTRODE; POLY(GLUTAMIC ACID); ELECTROCATALYTIC OXIDATION; PASTE ELECTRODE; PHARMACEUTICAL FORMULATIONS; ELECTROCHEMICAL SENSOR; COVALENT MODIFICATION;
D O I：
10.3390/chemosensors5030025
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
This work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydrochlorothiazide (HCTZ) by differential pulse voltammetry. Both electrochemical characterization and analytical performance indicate that SPCE/EGA is a much better sensor for HCTZ. The detection and quantification limits were at the level of mol L-1 with a very good linearity in the studied concentration range. In addition, the proposed SPCE/EGA was successfully applied for the determination of HCTZ in an anti-hypertensive drug with high reproducibility and good trueness.
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页数：12
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