The Role of NRF2/KEAP1 Pathway in Glioblastoma: Pharmacological Implications

被引：9

作者：

Shahcheraghi, Seyed Hossein ^{[1
,2
]}

Salemi, Fateme ^{[3
]}

Alam, Waqas ^{[4
]}

Ashworth, Henry ^{[5
]}

Saso, Luciano ^{[6
]}

Khan, Haroon ^{[4
]}

Lotfi, Marzieh ^{[2
,7
]}

机构：

[1] Shahid Sadoughi Univ Med Sci, Shahid Sadoughi Hosp, Infect Dis Res Ctr, Yazd, Iran

[2] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Yazd, Iran

[3] Islamic Azad Univ Med Sci, Sch Med, Yazd, Iran

[4] Abdul Wali Khan Univ Mardan, Dept Pharm, Mardan, Pakistan

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Sapienza Univ, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy

[7] Shahid Sadoughi Univ Med Sci, Reprod Sci Inst, Abort Res Ctr, Yazd, Iran

来源：

MEDICAL ONCOLOGY | 2022年 / 39卷 / 05期

关键词：

Glioblastoma multiforme; NF-E2-related factor 2; Kelch-like ECH-related protein 1; Therapeutic options; NRF2-ARE SIGNALING PATHWAY; NRF2/ARE PATHWAY; GLIOMA-CELLS; EXPRESSION; INDUCTION; CANCER; PROGRESSION; ACTIVATION; RESISTANCE; KNOCKDOWN;

D O I：

10.1007/s12032-022-01693-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma multiforme (GBM) grade IV glioma is the most frequent and deadly intracranial cancer. This tumor is determined by unrestrained progression, uncontroled angiogenesis, high infiltration and weak response to treatment, which is chiefly because of abnormal signaling pathways in the tumor. A member related to the Cap 'n' collar family of keypart-leucine zipper transcription agents-the transcription factor NF-E2-related factor 2 (Nrf2)-regulates adaptive protection answers by organized upregulation of many genes that produce the cytoprotective factors. In reply to cellular pressures types such as stresses, Nrf2 escapes Kelch-like ECH-related protein 1 (Keap1)-facilitated suppression, moves from the cytoplasm towards the nucleus and performs upregulation of gene expression of antioxidant responsive element (ARE). Nrf2 function is related tocontrolling many types of diseases in the human specially GBM tumor.Thus, we will review the epigeneticalregulatory actions on the Nrf2/Keapl signaling pathway and potential therapeutic options in GBM by aiming the stimulation of Nrf2.

引用

页数：10

共 78 条

[21] Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs [J].