Influence of sex on development of thrombosis in patients with COVID-19: From the CLOT-COVID study

被引：12

作者：

Yamashita, Yugo ^{[1
]}

Yachi, Sen ^{[2
]}

Takeyama, Makoto ^{[2
]}

Nishimoto, Yuji ^{[3
]}

Tsujino, Ichizo ^{[4
]}

Nakamura, Junichi ^{[4
]}

Yamamoto, Naoto ^{[5
]}

Nakata, Hiroko ^{[6
]}

Ikeda, Satoshi ^{[7
]}

Umetsu, Michihisa ^{[8
]}

Aikawa, Shizu ^{[9
]}

Hayashi, Hiroya ^{[10
]}

Satokawa, Hirono ^{[11
]}

Okuno, Yoshinori ^{[1
]}

Iwata, Eriko ^{[12
]}

Ogihara, Yoshito ^{[13
]}

Ikeda, Nobutaka ^{[14
]}

Kondo, Akane ^{[15
]}

Iwai, Takehisa ^{[16
]}

Yamada, Norikazu ^{[17
]}

Ogawa, Tomohiro ^{[18
]}

Kobayashi, Takao ^{[5
]}

Mo, Makoto ^{[19
]}

机构：

[1] Kyoto Univ Hosp, Kyoto, Japan

[2] Japan Community Hlth Care Org, Tokyo Shinjuku Med Ctr, Tokyo, Japan

[3] Hyogo Prefectural Amagasaki Gen Med Ctr, Amagasaki, Hyogo, Japan

[4] Hokkaido Univ Hosp, Sapporo, Hokkaido, Japan

[5] Hamamatsu Med Ctr, Hamamatsu, Shizuoka, Japan

[6] Yokosuka Gen Hosp Uwamachi, Yokosuka, Kanagawa, Japan

[7] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki, Japan

[8] Tohoku Univ Hosp, Sendai, Miyagi, Japan

[9] Tsukuba Med Ctr Hosp, Tsukuba, Ibaraki, Japan

[10] Osaka City Univ, Grad Sch Med, Osaka, Japan

[11] Fukushima Med Univ, Sch Med, Fukushima, Japan

[12] Japan Community Hlth Care Org, Nankai Med Ctr, Saiki, Japan

[13] Mie Univ Hosp, Tsu, Mie, Japan

[14] Toho Univ, Ohashi Med Ctr, Tokyo, Japan

[15] Shikoku Med Ctr Children & Adults, Zentsuji, Japan

[16] Tsukuba Vasc Ctr, Ibaraki, Japan

[17] Kuwana City Med Ctr, Kuwana, Japan

[18] Fukushima Daiich Hosp, Fukushima, Japan

[19] Yokohama Minami Kyosai Hosp, Yokohama, Kanagawa, Japan

来源：

THROMBOSIS RESEARCH | 2022年 / 213卷

关键词：

COVID-19; Thrombosis; Sex; CLINICAL CHARACTERISTICS; VENOUS THROMBOEMBOLISM; RISK; ANTICOAGULATION; MEN;

D O I：

10.1016/j.thromres.2022.03.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: There has been limited data on the influence of sex on development of thrombosis in patients with coronavirus disease 2019 (COVID-19). Materials and methods: The CLOT-COVID Study was a retrospective, multicenter cohort study enrolling 2894 consecutive hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We divided the entire cohort into the men (N = 1885) and women (N = 1009) groups. Results: There were no significant differences in D-dimer levels at admission between men and women. Men had more severe status of the COVID-19 at admission compared with women (Mild: 57% versus 66%, Moderate: 34% versus 29%, and Severe: 9.1% versus 5.7%, P < 0.001). Men more often received pharmacological thromboprophylaxis than women (47% versus 35%, P < 0.001). During the hospitalization, men more often developed thrombosis than women (2.5% [95%CI, 1.9-3.3%] versus 0.8% [95%CI, 0.4-1.6%], P = 0.001). Men had numerically higher incidences of thrombosis than women in all subgroups of the worst severity of COVID-19 during the hospitalization (Mild: 0.3% versus 0.0%, Moderate: 1.6% versus 1.0%, and Severe: 11.1% versus 4.3%). Even after adjusting confounders in the multivariable logistic regression model, the excess risk of men relative to women remained significant for thrombosis (adjusted OR, 2.51; 95%CI, 1.16-5.43, P = 0.02).

引用

页码：173 / 178

页数：6

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