Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection

被引：57
作者：
Meraldi, V
Nebié, I
Tiono, AB
Diallo, D
Sanogo, E
Theisen, M
Druilhe, P
Corradin, G [1 ]
Moret, R
Sirima, BS
机构：
[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland
[2] Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso
[3] Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen, Denmark
[4] Inst Pasteur, Lab Parasitol Med, Paris, France
来源：
PARASITE IMMUNOLOGY | 2004年 / 26卷 / 6-7期
关键词：
antibody; longitudinal study; malaria; Plasmodium falciparum; synthetic peptide; vaccine;
D O I：
10.1111/j.0141-9838.2004.00705.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy season to three long synthetic peptides corresponding to Plasmodium falciparum Exp-1 101-162, MSP-3 154-249 and GLURP 801-920 but not to CSP 274-375 correlated with a statistically significant decrease in malarial infection during the ongoing transmission season. The simultaneous presence of an antibody response to more than one antigen is indicative of a lower frequency of malarial infection. This gives scientific credibility to the notion that a successful malaria vaccine should contain multiple antigens.
引用
收藏
页码：265 / 272
页数：8
相关论文
共 41 条
[1]   ANTIBODIES TO PF155/RESA AND CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM IN PAIRED MATERNAL-CORD SERA FROM NIGERIA [J].
ACHIDI, EA ;
PERLMANN, H ;
SALIMONU, LS ;
ASUZU, MC ;
PERLMANN, P ;
BERZINS, K .
PARASITE IMMUNOLOGY, 1995, 17 (10) :535-540
[2]   POLYAMIDE METHOD OF SOLID-PHASE PEPTIDE AND OLIGONUCLEOTIDE SYNTHESIS [J].
ATHERTON, E ;
GAIT, MJ ;
SHEPPARD, RC ;
WILLIAMS, BJ .
BIOORGANIC CHEMISTRY, 1979, 8 (03) :351-370
[3]   USE OF A RECOMBINANT BACULOVIRUS PRODUCT TO MEASURE NATURALLY-ACQUIRED HUMAN-ANTIBODIES TO DISULFIDE-CONSTRAINED EPITOPES ON THE PLASMODIUM-FALCIPARUM MEROZOITE SURFACE PROTEIN-1 (MSP1) [J].
BLACKMAN, MJ ;
HOLDER, AA .
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 1993, 6 (04) :307-316
[4]   Malaria: Even more chronic in nature than previously thought; Evidence for subpatent parasitaemia detectable by the polymerase chain reaction [J].
Bottius, E ;
Guanzirolli, A ;
Trape, JF ;
Rogier, C ;
Konate, L ;
Druilhe, P .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1996, 90 (01) :15-19
[5]   ANTIBODIES THAT PROTECT HUMANS AGAINST PLASMODIUM-FALCIPARUM BLOOD STAGES DO NOT ON THEIR OWN INHIBIT PARASITE GROWTH AND INVASION INVITRO, BUT ACT IN COOPERATION WITH MONOCYTES [J].
BOUHAROUNTAYOUN, H ;
ATTANATH, P ;
SABCHAREON, A ;
CHONGSUPHAJAISIDDHI, T ;
DRUILHE, P .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (06) :1633-1641
[6]   MECHANISMS UNDERLYING THE MONOCYTE-MEDIATED ANTIBODY-DEPENDENT KILLING OF PLASMODIUM-FALCIPARUM ASEXUAL BLOOD STAGES [J].
BOUHAROUNTAYOUN, H ;
OEUVRAY, C ;
LUNEL, F ;
DRUILHE, P .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (02) :409-418
[7]   CD4+ T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein [J].
Charoenvit, Y ;
Majam, VF ;
Corradin, G ;
Sacci, JB ;
Wang, RB ;
Doolan, DL ;
Jones, TR ;
Abot, E ;
Patarroyo, ME ;
Guzman, F ;
Hoffman, SL .
INFECTION AND IMMUNITY, 1999, 67 (11) :5604-5614
[8]   PLASMODIUM-YOELII - 17-KDA HEPATIC AND ERYTHROCYTIC STAGE PROTEIN IS THE TARGET OF AN INHIBITORY MONOCLONAL-ANTIBODY [J].
CHAROENVIT, Y ;
MELLOUK, S ;
SEDEGAH, M ;
TOYOSHIMA, T ;
LEEF, MF ;
DELAVEGA, P ;
BEAUDOIN, RL ;
AIKAWA, M ;
FALLARME, V ;
HOFFMAN, SL .
EXPERIMENTAL PARASITOLOGY, 1995, 80 (03) :419-429
[9]   GAMMA-GLOBULIN AND ACQUIRED IMMUNITY TO HUMAN MALARIA [J].
COHEN, S ;
CARRINGTON, S ;
MCGREGOR, IA .
NATURE, 1961, 192 (480) :733-&
[10]   Conservation and heterogeneity of the glutamate-rich protein (GLURP) among field isolates and laboratory lines of Plasmodium faliparum [J].
de Stricker, K ;
Vuust, J ;
Jepsen, S ;
Oeuvray, C ;
Theisen, M .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2000, 111 (01) :123-130
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