FGFR3 mutations in epidermal nevi and seborrheic keratoses:: Lessons from urothelium and skin

被引：22
作者：
Hafner, Christian
Hartmann, Arndt
Vogt, Thomas
机构：
[1] Univ Regensburg, Dept Dermatol, D-93042 Regensburg, Germany
[2] Univ Regensburg, Inst Pathol, D-93042 Regensburg, Germany
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2007年 / 127卷 / 07期
关键词：
D O I：
10.1038/sj.jid.5700772
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Somatic FGFR3 mutations have been reported in various cancers such as urothelial carcinoma. Evidence is growing that these mutations are also involved in the pathogenesis of benign acanthotic skin tumors such as epidermal nevi and seborrheic keratoses. The report by Hernandez et al. strongly supports this concept. However, further studies are required for a better pathogenetic understanding of FGFR3 related tumors in urothelium and skin.
引用
收藏
页码：1572 / 1573
页数：2
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