Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses

被引：69

作者：

Perry, DK ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Biochem & Mol Biol, Hollings Canc Ctr, Charleston, SC 29403 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2002年 / 1585卷 / 2-3期

关键词：

serine palmitoyltransferase; ceramide; stress response;

D O I：

10.1016/S1388-1981(02)00335-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Serine palmitoyltransferase is the first and rate-limiting enzyme of sphingolipid synthesis. As such, it is a central control point in the synthesis of bioactivate sphingolipids, and it plays an important role in mediating cellular stress responses. In this review, its role in mediating these responses is discussed within the context of de novo ceramide synthesis. Furthermore, a discussion is provided of its regulation as discerned from both yeast and mammalian studies. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：146 / 152

页数：7

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