AMPK signalling in health and disease

被引：619

作者：

Carling, David ^{[1
]}

机构：

[1] Imperial Coll, Hammersmith Hosp, MRC London Inst Med Sci, London W12 0NN, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2017年 / 45卷

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; PARKINSON-WHITE-SYNDROME; GAMMA-SUBUNIT ISOFORMS; SKELETAL-MUSCLE; HYPERTROPHIC CARDIOMYOPATHY; STRUCTURAL BASIS; UPSTREAM KINASE; VENTRICULAR PREEXCITATION; CARDIAC-HYPERTROPHY; MUTATION;

D O I：

10.1016/j.ceb.2017.01.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide levels, being activated by an increase in AMP/ADP relative to ATP. Activation of AMPK increases the rate of catabolic (ATP-generating) pathways and decreases the rate of anabolic (ATP-utilising) pathways. In addition to its role in maintaining intracellular energy balance, AMPK regulates whole body energy metabolism. Given its key role in controlling energy homeostasis, AMPK has attracted widespread interest as a potential therapeutic target for metabolic diseases, including type 2 diabetes and, more recently, cancer. Here I review the regulation of AMPK and its potential as a target for therapeutic intervention in human disease.

引用

页码：31 / 37

页数：7

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