Vogt-Koyanagi-Harada Disease following mRNA-1273 (Moderna) COVID-19 Vaccination

被引：10
作者：
Joo, Chan Woong [1 ]
Kim, Yong-Kyu [1 ]
Park, Sung Pyo [1 ]
机构：
[1] Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, Dept Ophthalmol, 150 Seongan Ro, Seoul 05355, South Korea
来源：
OCULAR IMMUNOLOGY AND INFLAMMATION | 2022年 / 30卷 / 05期
关键词：
COVID-19; vaccine; mRNA-1273 (moderna); SARS-CoV-2; vaccine side effects; vogt-koyanagi-harada disease;
D O I：
10.1080/09273948.2022.2053547
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: To report a case of Vogt-Koyanagi-Harada (VKH) disease following mRNA-1273 (Moderna) COVID-19 vaccination. Methods: Retrospective case report. Results: A 50-year-old Korean woman developed bilateral serous retinal detachment 35 days after the first dose of COVID-19 mRNA vaccination (mRNA-1273, Moderna). She experienced adverse effects such as erythema and pain at the injection site, headache, myalgia, and allergy symptoms prior to ocular manifestation. She was diagnosed with Vogt-Koyanagi-Harada (VKH) disease. After treatment with oral prednisolone, the serous retinal detachment resolved and vision improved. Conclusion: COVID-19 vaccination might be associated with VKH disease development, and the ingredients of the mRNA vaccine or viral peptide encoded by mRNA may have activated the immunological process and induced VKH disease.
引用
收藏
页码：1250 / 1254
页数：5
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