Engineering the surface of Gd2O3 nanoplates for improved T1-weighted magnetic resonance imaging

被引：28

作者：

Cai, Wen ^{[1
]}

Zhang, Yang ^{[2
]}

Wang, Junqing ^{[2
]}

Wang, Zhiyong ^{[3
]}

Tian, Ye ^{[2
]}

Liu, Heng ^{[4
]}

Pan, Hongzhi ^{[5
]}

Fu, Li ^{[6
]}

Chen, Wei ^{[1
]}

Wu, Chunsheng ^{[1
]}

Wang, Xiaoyong ^{[2
]}

Liu, Gang ^{[2
]}

机构：

[1] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Inst Med Engn,Dept Biophys, Xian 710061, Shaanxi, Peoples R China

[2] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Fujian, Peoples R China

[3] Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China

[4] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Shaanxi, Peoples R China

[5] Shanghai Univ Med & Hlth Sci, Coll Med Technol, Shanghai 201308, Peoples R China

[6] Hangzhou Dianzi Univ, Coll Mat & Environm Engn, Hangzhou 310018, Zhejiang, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2020年 / 380卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Gd2O3; nanoplates; Cluster; Magnetic resonance imaging (MRI); Biocompatible; GADOLINIUM-OXIDE; DRUG-DELIVERY; NANOPARTICLES; AGENTS; T-1;

D O I：

10.1016/j.cej.2019.122473

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The oleic acid (OA) and oleylamine (OM)-capped Gd2O3 nanoplates were encapsulated into N-Dodecyl-PEI-PEG polymer to synthesize the hydrophilic clusters for T1-weighted magnetic resonance imaging (MRI). The obtained Gd2O3@N-Dodecyl-PEI-PEG clusters showed a hydrodynamic size of 95 nm and a r1 value of 14.13 mM(-1 )s(-1), which was approximately 4 times greater than that of the commercial product gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) (r1 = 3.40 mM(-1) s(-1)). The in vitro toxicity demonstrated that the obtained clusters were biocompatible. The MRI experiments on SCC-7 cells/xenograft tumors indicated that the clusters had obvious T1-enhancement ability. These clusters have great potential application as T1-weighted MRI contrast agents.

引用

页数：7

共 28 条

[1] Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Enhancement [J].

Ahren, Maria ;

Selegard, Linnea ;

Klasson, Anna ;

Soderlind, Fredrik ;

Abrikossova, Natalia ;

Skoglund, Caroline ;

Bengtsson, Torbjorn ;

Engstrom, Maria ;

Kall, Per-Olov ;

Uvdal, Kajsa .

LANGMUIR, 2010, 26 (08) :5753-5762

[2] Preparation and luminescent properties of GdOF:Ce, Tb nanoparticles and their transparent PMMA nanocomposites [J].

Cai, Wen ;

Wang, Aiwu ;

Fu, Li ;

Hu, Jie ;

Rao, Tingke ;

Wang, Junqing ;

Zhong, Jiasong ;

Xiang, Weidong .

OPTICAL MATERIALS, 2015, 43 :36-41

[3] Synthesis of square gadolinium-oxide nanoplates [J].

Cao, YC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (24) :7456-7457

[4] Polymer-based gadolinium oxide nanocomposites for FL/MR/PA imaging guided and photothermal/photodynamic combined anti-tumor therapy [J].

Cheng, Yu ;

Tan, Xiaoxiao ;

Wang, Jinping ;

Wang, Yidan ;

Song, Yilin ;

You, Qing ;

Sun, Qi ;

Liu, Li ;

Wang, Siyu ;

Tan, Fengping ;

Li, Jiao ;

Li, Nan .

JOURNAL OF CONTROLLED RELEASE, 2018, 277 :77-88

[5] Gadolinium oxide nanoplates with high longitudinal relaxivity for magnetic resonance imaging [J].

Cho, Minjung ;

Sethi, Richa ;

Narayanan, Jeyarama Subramanian Ananta ;

Lee, Seung Soo ;

Benoit, Denise N. ;

Taheri, Nasim ;

Decuzzi, Paolo ;

Colvin, Vicki L. .

NANOSCALE, 2014, 6 (22) :13637-13645

[6] Manipulating the surface coating of ultra-small Gd2O3 nanoparticles for improved T1-weighted MR imaging [J].

Fang, Jie ;

Chandrasekharan, Prashant ;

Liu, Xiao-Li ;

Yang, Yong ;

Lv, Yun-Bo ;

Yang, Chang-Tong ;

Ding, Jun .

BIOMATERIALS, 2014, 35 (05) :1636-1642

[7] Inorganic nanoparticle-based T1 and T1/T2 magnetic resonance contrast probes [J].

Hu, Fengqin ;

Zhao, Yong Sheng .

NANOSCALE, 2012, 4 (20) :6235-6243

[8] AS1411 aptamer-conjugated Gd2O3:Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging [J].

Kuo, Tsungrong ;

Lai, Weiyun ;

Li, Chenghung ;

Wun, Yanjhan ;

Chang, Huancheng ;

Chen, Jinnshiun ;

Yang, Panchyr ;

Chen, Chiachun .

NANO RESEARCH, 2014, 7 (05) :658-669

[9]

LaConte L., 2005, Nanotoday, V19, P32, DOI DOI 10.1016/S1369-7021(05)00893-X

[10] N-Alkyl-PEI-Functionalized Iron Oxide Nanoclusters for Efficient siRNA Delivery [J].

Liu, Gang ;

Xie, Jin ;

Zhang, Fan ;

Wang, Zhiyong ;

Luo, Kui ;

Zhu, Lei ;

Quan, Qimeng ;

Niu, Gang ;

Lee, Seulki ;

Ai, Hua ;

Chen, Xiaoyuan .

SMALL, 2011, 7 (19) :2742-2749

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