Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma

被引：14
|
作者：
Zhou, Weizheng [1 ]
Yue, Hui [2 ]
Li, Chunguang [1 ]
Chen, Hezhong [1 ]
Yuan, Yang [1 ]
机构：
[1] Second Mil Med Univ, Changhai Hosp, Dept Cardiothorac Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China
[2] Second Peoples Hosp Hefei, Dept Thorac Surg, Hefei 230011, Anhui, Peoples R China
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 02期
关键词：
ESCC; PRMT1; Hedgehog signaling; Cell growth and migration; HEDGEHOG SIGNALING PATHWAY; PRMT1; REGULATOR;
D O I：
10.1007/s13277-015-4098-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Dysregulation of protein arginine methyltransferase 1 (PRMT1) has been reported in several cancer types. However, its expression pattern and biological functions in esophageal squamous cell carcinoma (ESCC) remained unknown. Here, we have found that the expression of PRMT1 was up-regulated in ESCC samples. In the biological function studies, forced expression of PRMT1 promoted the growth and migration of ESCC cells. However, knocking down the expression of PRMT1 inhibited the growth, migration, and metastasis of ESCC cells. Moreover, PRMT1 activated Hedgehog signaling and up-regulated the expression of target genes downstream of Hedgehog signaling. Taken together, our study revealed the oncogenic roles of PRMT1 in the progression of ESCC, and PRMT1 might be a promising therapeutic target for the treatment of ESCC.
引用
收藏
页码：2613 / 2619
页数：7
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