The effects of zinc treatment on matrix metalloproteinases: A systematic review

被引：34
作者：
Nosrati, Rahmat [1 ]
Kheirouri, Sorayya [1 ]
Ghodsi, Ramin [1 ]
Ojaghi, Habib [2 ]
机构：
[1] Tabriz Univ Med Sci, Dept Nutr, Tabriz, Iran
[2] Ardabil Univ Med Sci, Dept Ophthalmol, Ardebil, Iran
来源：
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2019年 / 56卷
关键词：
Zn; Matrix metalloproteinases; Oxidative stress; Tissue inhibitors of metalloproteinases; Antioxidant; Gelatinases; OXIDATIVE STRESS; GELATINASES MMP-2; SIGNALING PATHWAY; P38; MAPK; IN-VITRO; KAPPA-B; ACTIVATION; INHIBITION; EXPRESSION; CANCER;
D O I：
10.1016/j.jtemb.2019.08.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: Zinc (Zn) acts as a cofactor of matrix metalloproteinases (MMPs) and is vital for their activity and controlling their expression. Alteration of Zn in the body could affect the expression, activity, and destructive impacts of MMPs. Objective: This systematic review aimed to summarize existing evidence on the effects of Zn treatment on the expression and activity of MMPs. Method: International sources from Pub Med, Scopus and Google Scholar were searched for the original and English-language studies, published up to the end of May 2018. Results: During the initial search, 179 records were found, and 135 articles of them remained after the exclusion of duplicate articles. 47 studies met the inclusion criteria, after multiple stages of screening and critical reviews of articles. Conclusion: Approximately 62% of the included studies (29 of 47) showed an inhibitory impact of Zn on MMPs production and activities. The inhibitory or stimulatory effect of Zn on MMPs seems to depend on physiological conditions of the cells or animals used, dose of Zn used, and duration of treatment.
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页码：107 / 115
页数：9
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