The immunopathology of sepsis and potential therapeutic targets

被引：1438

作者：

van der Poll, Tom ^{[1
,2
]}

van de Veerdonk, Frank L. ^{[3
,4
]}

Scicluna, Brendon P. ^{[1
,5
]}

Netea, Mihai G. ^{[3
,4
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Ctr Expt & Mol Med, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Div Infect Dis, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[3] Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Geert Grooteplein Zuid 8, NL-6525 GA Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Ctr Infect Dis, Med Ctr, Geert Grooteplein Zuid 8, NL-6525 GA Nijmegen, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 07期

基金：

欧洲研究理事会;

关键词：

ADAPTIVE IMMUNE DYSFUNCTION; POLYMYXIN-B HEMOPERFUSION; INTENSIVE-CARE-UNIT; SEPTIC SHOCK; CYTOKINE PRODUCTION; THYMOSIN ALPHA-1; HOST RESPONSE; RISK STRATIFICATION; ACQUIRED PNEUMONIA; INTERFERON-GAMMA;

D O I：

10.1038/nri.2017.36

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. In sepsis, the immune response that is initiated by an invading pathogen fails to return to homeostasis, thus culminating in a pathological syndrome that is characterized by sustained excessive inflammation and immune suppression. Our understanding of the key mechanisms involved in the pathogenesis of sepsis has increased tremendously, yet this still needs to be translated into novel targeted therapeutic strategies. Pivotal for the clinical development of new sepsis therapies is the selection of patients on the basis of biomarkers and/or functional defects that provide specific insights into the expression or activity of the therapeutic target.

引用

页码：407 / 420

页数：14

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