Autonomic Nervous System in Obesity and Insulin-Resistance-The Complex Interplay between Leptin and Central Nervous System

被引：59

作者：

Russo, Benedetta ^{[1
,2
]}

Menduni, Marika ^{[1
,2
]}

Borboni, Patrizia ^{[1
,2
]}

Picconi, Fabiana ^{[1
]}

Frontoni, Simona ^{[1
,2
]}

机构：

[1] Fatebenefratelli Hosp, S Giovanni Calibita, Unit Endocrinol Diabet & Metab, I-00186 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 10期

关键词：

autonomic nervous system (ANS); leptin; insulin-resistance; central nervous system (CNS); CIRCADIAN DYSFUNCTION; INSUFFICIENT SLEEP; ENERGY-EXPENDITURE; BLOOD-PRESSURE; FOOD-INTAKE; HYPERTENSION; ACTIVATION; RESPONSES; NEURONS; HYPERINSULINEMIA;

D O I：

10.3390/ijms22105187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of the autonomic nervous system in obesity and insulin-resistant conditions has been largely explored. However, the exact mechanisms involved in this relation have not been completely elucidated yet, since most of these mechanisms display a bi-directional effect. Insulin-resistance, for instance, can be caused by sympathetic activation, but, in turn, the associated hyperinsulinemia can activate the sympathetic branch of the autonomic nervous system. The picture is made even more complex by the implicated neural, hormonal and nutritional mechanisms. Among them, leptin plays a pivotal role, being involved not only in appetite regulation and glucose homeostasis but also in energy expenditure. The purpose of this review is to offer a comprehensive view of the complex interplay between leptin and the central nervous system, providing further insights on the impact of autonomic nervous system balance on adipose tissue and insulin-resistance. Furthermore, the link between the circadian clock and leptin and its effect on metabolism and energy balance will be evaluated.

引用

页数：12

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