Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

被引：4
作者：
Lin, Hungyen [1 ,2 ]
Pei, Chunlei [3 ]
Markl, Daniel [2 ]
Shen, Yaochun [4 ]
Elliott, James A. [3 ]
Zeitler, J. Axel [2 ]
机构：
[1] Univ Lancaster, Dept Engn, Lancaster LA1 4YW, England
[2] Univ Cambridge, Dep Chem Engn & Biotechnol, Philippa Fawcett Dr, Cambridge CB3 0AS, England
[3] Univ Cambridge, Dept Mat Sci & Met, 27 Charles Babbage Rd, Cambridge CB3 0FS, England
[4] Univ Liverpool, Dept Elect Engn & Elect, Brownlow Hill, Liverpool L69 3GJ, Merseyside, England
来源：
IET MICROWAVES ANTENNAS & PROPAGATION | 2018年 / 12卷 / 11期
基金：
英国工程与自然科学研究理事会;
关键词：
pharmaceuticals; coatings; pharmaceutical industry; ray tracing; mixing; discrete element method; numerical verification; tablet mixing; discrete element modelling; terahertz in-line sensing; film coating thickness; individual pharmaceutical tablets; measurement analysis; cumulative measurements; discrete modelling; tablet pan coater; artificial lab-scale tablet; terahertz in-line measurement modality; off-line measurements; in-line measurements; coating process; OPTICAL COHERENCE TOMOGRAPHY; PAN COATING PROCESS; DEM; VALIDATION; SIMULATION;
D O I：
10.1049/iet-map.2018.5561
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.
引用
收藏
页码：1775 / 1779
页数：5
相关论文
共 18 条
  • [1] Analysis of large-scale tablet coating: Modeling, simulation and experiments
    Boehling, P.
    Toschkoff, G.
    Knop, K.
    Kleinebudde, P.
    Just, S.
    Funke, A.
    Rehbaum, H.
    Khinast, J. G.
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 90 : 14 - 24
  • [2] Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes
    Di Renzo, A
    Di Maio, FP
    [J]. CHEMICAL ENGINEERING SCIENCE, 2004, 59 (03) : 525 - 541
  • [3] Comparisons of intra-tablet coating variability using DEM simulations, asymptotic limit models, and experiments
    Freireich, Ben
    Kumar, Rahul
    Ketterhagen, William
    Su, Ke
    Wassgren, Carl
    Zeitler, J. Axel
    [J]. CHEMICAL ENGINEERING SCIENCE, 2015, 131 : 197 - 212
  • [4] Intra-particle coating variability: Analysis and Monte-Carlo simulations
    Freireich, Ben
    Wassgren, Carl
    [J]. CHEMICAL ENGINEERING SCIENCE, 2010, 65 (03) : 1117 - 1124
  • [5] Models, algorithms and validation for opensource DEM and CFD-DEM
    Kloss, Christoph
    Goniva, Christoph
    Hager, Alice
    Amberger, Stefan
    Pirker, Stefan
    [J]. PROGRESS IN COMPUTATIONAL FLUID DYNAMICS, 2012, 12 (2-3): : 140 - 152
  • [6] Lin H., 2017, UK EUR CHIN WORKSH M, P1
  • [7] Pharmaceutical Film Coating Catalog for Spectral Domain Optical Coherence Tomography
    Lin, Hungyen
    Dong, Yue
    Markl, Daniel
    Zhang, Zijian
    Shen, Yaochun
    Zeitler, J. Axel
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 106 (10) : 3171 - 3176
  • [8] Measurement of the Intertablet Coating Uniformity of a Pharmaceutical Pan Coating Process With Combined Terahertz and Optical Coherence Tomography In-Line Sensing
    Lin, Hungyen
    Dong, Yue
    Markl, Daniel
    Williams, Bryan M.
    Zheng, Yalin
    Shen, Yaochun
    Zeitler, J. Axel
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 106 (04) : 1075 - 1084
  • [9] Quantifying Pharmaceutical Film Coating with Optical Coherence Tomography and Terahertz Pulsed Imaging: An Evaluation
    Lin, Hungyen
    Dong, Yue
    Shen, Yaochun
    Zeitler, J. Axel
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 104 (10) : 3377 - 3385
  • [10] Impact of Processing Conditions on Inter-tablet Coating Thickness Variations Measured by Terahertz In-Line Sensing
    Lin, Hungyen
    May, Robert K.
    Evans, Michael J.
    Zhong, Shuncong
    Gladden, Lynn F.
    Shen, Yaochun
    Zeitler, J. Axel
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 104 (08) : 2513 - 2522
12