Iridium-Catalyzed Enantioselective Allylic Substitution of O-Allyl Carbamothioates

被引：29

作者：

Xu, Qing-Long ^{[1
]}

Liu, Wen-Bo ^{[1
]}

Dai, Li-Xin ^{[1
]}

You, Shu-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 13期

基金：

中国国家自然科学基金;

关键词：

S BOND FORMATION; ASYMMETRIC-SYNTHESIS; KINETIC RESOLUTION; AMINATION; ETHERIFICATION; COMPLEXES; ALCOHOLS; THIOLS; HETEROCYCLES; ALKYLATION;

D O I：

10.1021/jo1006152

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With an [Ir(COD)Cl](2)/phosphoramidite ligand system, an allylic substitution of O-allyl carbamothioates was developed. The reaction proceeded in the favor of branched products with up to 93:7 branched-to-linear ratio, affording chiral S-allyl carbamothioates with up to 95% ee.

引用

页码：4615 / 4618

页数：4

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