Survival of breast cancer patients according to changes in expression of selected markers between primary tumor and lymph node metastases

被引：12

作者：

Adamczyk, Agnieszka ^{[1
]}

Niemiec, Joanna ^{[1
]}

Ambicka, Aleksandra ^{[2
]}

Mucha-Malecka, Anna ^{[3
]}

Rys, Janusz ^{[2
]}

Mitus, Jerzy ^{[4
]}

Wysocki, Wojciech M. ^{[4
]}

Cichocka, Anna ^{[1
]}

Jakubowicz, Jerzy ^{[3
]}

机构：

[1] Maria Sklodowska Curie Mem Canc Ctr & Inst Oncol, Dept Appl Radiobiol, Cracow Branch, Garncarska 11, PL-31115 Krakow, Poland

[2] Maria Sklodowska Curie Mem Canc Ctr & Inst Oncol, Dept Tumor Pathol, Cracow Branch, Garncarska 11, PL-31115 Krakow, Poland

[3] Maria Sklodowska Curie Mem Canc Ctr & Inst Oncol, Clin Oncol, Cracow Branch, Garncarska 11, PL-31115 Krakow, Poland

[4] Maria Sklodowska Curie Mem Canc Ctr & Inst Oncol, Dept Surg Oncol, Cracow Branch, Garncarska 11, PL-31115 Krakow, Poland

来源：

BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 03期

关键词：

breast carcinoma; changes in proteins expression; lymph node metastases; primary tumor; ALDEHYDE DEHYDROGENASE 1; RECEPTOR STATUS; CELLS; HER2; RECOMMENDATIONS; DISCORDANCE; BIOMARKERS; LESIONS; SITES; KI-67;

D O I：

10.2217/bmm.15.123

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The differences between primary and metastatic tumor cells might be important for treatment selection and prognostication. Materials & methods: Expression of ER, PR, HER2, CK5/6, EGFR, Ki-67, Ep-CAM, P-cadherin, CD24, CD44, ALDH was assessed immunohistochemically in primary tumor (T) and corresponding synchronous nodal metastases (LNM) in 156 invasive ductal breast cancer patients (T >= 1, N >= 1, M0). Results: Independent negative prognostic factors for disease-free survival were pN3, ALDH immunopositivity in LNM, nonluminal A subtype in LNM, reduction of Ep-CAM expression in LNM, lack of changes or enhancement of CK5/6 and ALDH expression in LNM. Discussion: Our results suggest that in some cases expression of markers in lymph node metastases might bring additional prognostic information to that obtained from primary tumor.

引用

页码：219 / 228

页数：10

共 37 条

[1] EXPRESSION OF ER/PR/HER2, BASAL MARKERS AND ADHESION MOLECULES IN PRIMARY BREAST CANCER AND IN LYMPH NODES METASTASES: A COMPARATIVE IMMUNOHISTOCHEMICAL ANALYSIS [J].

Adamczyk, Agnieszka ;

Niemiec, Joanna ;

Ambicka, Aleksandra ;

Malecki, Krzysztof ;

Wysocki, Wojciech H. ;

Mitus, Jerzy ;

Rys, Janusz .

POLISH JOURNAL OF PATHOLOGY, 2012, 63 (04) :228-234

[2]

[Anonymous], MOL CANCER

[3] Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages:: A new cell biological concept [J].

Böcker, W ;

Moll, R ;

Poremba, C ;

Holland, R ;

van Diest, PJ ;

Dervan, P ;

Bürger, H ;

Wai, D ;

Diallo, RI ;

Brandt, B ;

Herbst, H ;

Schmidt, A ;

Lerch, MM ;

Buchwallow, IB .

LABORATORY INVESTIGATION, 2002, 82 (06) :737-745

[4] Comparison of hormonal receptor and HER-2 status between breast primary tumours and relapsing tumours: clinical implications of progesterone receptor loss [J].

Bogina, Giuseppe ;

Bortesi, Laura ;

Marconi, Marcella ;

Venturini, Marco ;

Lunardi, Gianluigi ;

Coati, Francesca ;

Massocco, Alberto ;

Manfrin, Erminia ;

Pegoraro, Cristina ;

Zamboni, Giuseppe .

VIRCHOWS ARCHIV, 2011, 459 (01) :1-10

[5] Comparison of Her-2, EGFR and Cyclin D1 in Primary Breast Cancer and Paired Metastatic Lymph Nodes: An Immunohistochemical and Chromogenic In Situ Hybridization Study [J].

Cho, Eun Yoon ;

Han, Jae Joon ;

Choi, Yoon-La ;

Kim, Kyoung-Mee ;

Oh, Young Lyun .

JOURNAL OF KOREAN MEDICAL SCIENCE, 2008, 23 (06) :1053-1061

[6] Metastatic progression of breast cancer: insights from 50 years of autopsies [J].

Cummings, Margaret C. ;

Simpson, Peter T. ;

Reid, Lynne E. ;

Jayanthan, Janani ;

Skerman, Joanna ;

Song, Sarah ;

Reed, Amy E. McCart ;

Kutasovic, Jamie R. ;

Morey, Adrienne L. ;

Marquart, Louise ;

O'Rourke, Peter ;

Lakhani, Sunil R. .

JOURNAL OF PATHOLOGY, 2014, 232 (01) :23-31

[7] Correlation between genetic and biological aspects in primary non-metastatic breast cancers and corresponding synchronous axillary lymph node metastasis [J].

D'Andrea, Mario R. ;

Limiti, Maria R. ;

Bari, Mario ;

Zambenedetti, Pamela ;

Montagutti, Adriana ;

Ricci, Francesca ;

Pappagallo, Giovanni L. ;

Sartori, Donata ;

Vinante, Orazio ;

Mingazzini, Pietro L. .

BREAST CANCER RESEARCH AND TREATMENT, 2007, 101 (03) :279-284

[8] Biological characteristics of breast cancer at the primary tumour and the involved lymph nodes [J].

Dikicioglu, E ;

Barutca, S ;

Meydan, N ;

Meteoglu, I .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2005, 59 (09) :1039-1044

[9] The expression of aldehyde dehydrogenase 1 in invasive primary breast tumors and axillary lymph node metastases is associated with poor clinical prognosis [J].

Dong, Yi ;

Bi, Li-Rong ;

Xu, Ning ;

Yang, Hong-Mei ;

Zhang, Hai-Tao ;

Ding, Ying ;

Shi, Ai-Ping ;

Fan, Zhi-Min .

PATHOLOGY RESEARCH AND PRACTICE, 2013, 209 (09) :555-561

[10] Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group [J].

Dowsett, Mitch ;

Nielsen, Torsten O. ;

A'Hern, Roger ;

Bartlett, John ;

Coombes, R. Charles ;

Cuzick, Jack ;

Ellis, Matthew ;

Henry, N. Lynn ;

Hugh, Judith C. ;

Lively, Tracy ;

McShane, Lisa ;

Paik, Soon ;

Penault-Llorca, Frederique ;

Prudkin, Ljudmila ;

Regan, Meredith ;

Salter, Janine ;

Sotiriou, Christos ;

Smith, Ian E. ;

Viale, Giuseppe ;

Zujewski, Jo Anne ;

Hayes, Daniel F. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (22) :1656-1664

← 1 2 3 4 →