Histamine Reduces Flash Sensitivity of ON Ganglion Cells in the Primate Retina

被引:16
作者
Akimov, Nikolay P. [2 ]
Marshak, David W. [3 ]
Frishman, Laura J. [4 ]
Glickman, Randolph D. [1 ]
Yusupov, Rafail G. [3 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA
[3] Univ Texas Houston, Sch Med, Dept Neurobiol & Anat, Houston, TX 77225 USA
[4] Univ Houston, Coll Optometry, Houston, TX USA
关键词
DARK-ADAPTED ELECTRORETINOGRAM; VISUAL SENSITIVITY; MACAQUE RETINA; BIPOLAR CELLS; LIGHT ADAPTATION; ROD VISION; Y-CELL; MONKEY; HUMANS; SYSTEM;
D O I
10.1167/iovs.09-4806
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE. In Old World primates, the retina receives input from histaminergic neurons in the posterior hypothalamus. They are a subset of the neurons that project throughout the central nervous system and fire maximally during the day. The contribution of these neurons to vision, was examined by applying histamine to a dark-adapted, superfused baboon eye cup preparation while making extracellular recordings from peripheral retinal ganglion cells. METHODS. The stimuli were 5-ms, 560-nm, weak, full-field flashes in the low scotopic range. Ganglion cells with sustained and transient ON responses and two cell types with OFF responses were distinguished; their responses were recorded with a 16-channel microelectrode array. RESULTS. Low micromolar doses of histamine decreased the rate of maintained firing and the light sensitivity of ON ganglion cells. Both sustained and transient ON cells responded similarly to histamine. There were no statistically significant effects of histamine in a more limited study of OFF ganglion cells. The response latencies of ON cells were approximately 5 ms slower, on average, when histamine was present. Histamine also reduced the signal-to-noise ratio of ON cells, particularly in those cells with a histamine-induced increase in maintained activity. CONCLUSIONS. A major action of histamine released from retinopetal axons under dark-adapted conditions, when rod signals dominate the response, is to reduce the sensitivity of ON ganglion cells to light flashes. These findings may relate to reports that humans are less sensitive to light stimuli in the scotopic range during the day, when histamine release in the retina is expected to be at its maximum. (Invest Ophthalmol Vis Sci. 2010;51:3825-3834) DOI:10.1167/iovs.09-4806
引用
收藏
页码:3825 / 3834
页数:10
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