Gastroenteropancreatic neuroendocrine tumours (GEP-NET) - Imaging and staging

被引：69

作者：

Baumann, Tobias ^{[1
]}

Rottenburger, Christof ^{[2
,3
]}

Nicolas, Guillaume ^{[2
,4
]}

Wild, Damian ^{[2
,3
]}

机构：

[1] Univ Basel Hosp, Clin Radiol & Nucl Med, Radiol, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Clin Radiol & Nucl Med, Nucl Med, CH-4031 Basel, Switzerland

[3] Univ Basel Hosp, Ctr Neuroendocrine & Endocrine Tumors, Nucl Med, CH-4031 Basel, Switzerland

[4] Royal Free Hosp, Neuroendocrine Tumour Unit, Nucl Med, Pond St, London NW3 2QG, England

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2016年 / 30卷 / 01期

关键词：

GEP NET; gastroenteropancreatic neuroendocrine tumour; somatostatin receptor imaging; SRS; glucagon-like peptide-1 receptor imaging; PET/CT; POSITRON-EMISSION-TOMOGRAPHY; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; ENETS CONSENSUS GUIDELINES; GLUCAGON-LIKE PEPTIDE-1; SMALL-BOWEL NEOPLASMS; PREOPERATIVE LOCALIZATION; GA-68-DOTATATE PET/CT; LIVER METASTASES; CARCINOID-TUMORS; IN-VITRO;

D O I：

10.1016/j.beem.2016.01.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Detection of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) and monitoring of treatment response relies mainly on morphological imaging such as computed tomography (CT) and magnetic resonance imaging (MRI). Molecular imaging techniques also in combination with CT (hybrid imaging) greatly benefit patient management, including better localization of occult tumours and better staging. Somatostatin receptor scintigraphy (SRS) and somatostatin receptor (SSTR) positron emission tomography (PET) play a central role in the diagnostic work-up of patients with well differentiated GEP-NETS. SSTR PET/CT is superior to SRS and should be used whenever available. F-18-DOPA and F-18-FDG PET/CT is inferior to SSTR PET/CT at least in patients with well-differentiated GEP-NETs. Both SSTR PET/CT and SRS have limitations, such as relatively low detection rate of benign insulinomas, poorly differentiated GEP-NETS and liver metastases. New innovations such as SSTR PET/MRI, radiolabelled SSTR antagonists and glucagon-like peptide-1 receptor (GLP-1R) agonists might further improve imaging of GEP-NETS. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：45 / 57

页数：13

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