Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K

被引：67

作者：

Altmann, E ^{[1
]}

Cowan-Jacob, SW ^{[1
]}

Missbach, M ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, CH-4002 Basel, Switzerland

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 24期

关键词：

D O I：

10.1021/jm0493111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Starting from the high-throughput screening hit la, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.

引用

页码：5833 / 5836

页数：4

共 17 条

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