New insights on diclofenac electrochemistry using graphite as working electrode

被引:40
作者
Aguilar-Lira, G. Y. [1 ]
Alvarez-Romero, G. A. [1 ]
Zamora-Suarez, A. [1 ]
Palomar-Pardave, M. [2 ]
Rojas-Hernandez, A. [3 ]
Rodriguez-Avila, J. A. [1 ]
Paez-Hernandez, M. E. [1 ]
机构
[1] Univ Autonoma Estado Hidalgo, Area Acad Quim, Carretera Pachuca Tulancingo Km 4-5, Mineral De La Reforma 42076, Hidalgo, Mexico
[2] Univ Autonoma Metropolitan Azcapotzalco, Dept Mat, Av San Pablo Xalpa 180, Mexico City 02200, DF, Mexico
[3] Univ Autonoma Metropolitana Iztapalapa, Area Quim Analit, Av San Rafael Atlixco 186 Col Vicentina, Mexico City 09340, DF, Mexico
关键词
Graphite electrode; Cyclic voltammetry; Diclofenac characterization; Pharmaceuticals; Urine; WALL CARBON NANOTUBES; VOLTAMMETRIC DETERMINATION; PASTE ELECTRODE; SODIUM; OXIDATION; URINE; CHROMATOGRAPHY; SAMPLES; PLASMA;
D O I
10.1016/j.jelechem.2017.03.050
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
This paper reports new investigation on the electrochemical behavior of diclofenac using a bare graphite electrode. The electrochemical oxidation of diclofenac was studied using cyclic voltammetry (CV), an anodic peak was found at 0.557 V as reported earlier by other authors, reversing the cycle results in a new cathodic peak at 0.272 V, which is proposed to be related with the reduction of 2-(2hydroxyprop-2-enyl) acetic acid. During the second cycle a new cathodic peak is observed at 0.333 V, associated to the oxidation of 2-(2hydroxyprop-2-enyl) acetic acid to 1-hydroxy-2-(hydroxyphenyl) ethanalate. Both electrochemical processes resulted to be adsorption-controlled, statistical fit of theoretical information with the experimental voltammograms, one electron transference is demonstrated which supports the proposed mechanism. From an analytical point of view, it was demonstrated that direct quantification of diclofenac using the anodic oxidation peak results less favorable when compared with an indirect quantification using the 2-(2hydroxyprop-2-enyl) acetic acid oxidation peak. The modified Simplex method was used to optimize differential pulse voltammetry parameters to achieve an exact and precise quantification of diclofenac in standard and real samples obtaining very competitive results compared with other more sophisticated working electrodes.
引用
收藏
页码:182 / 188
页数:7
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