Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione derivatives

被引：15

作者：

Kim, BY ^{[1
]}

Ahn, JB ^{[1
]}

Lee, HW ^{[1
]}

Moon, KS ^{[1
]}

Sim, TB ^{[1
]}

Shin, JS ^{[1
]}

Ahn, SK ^{[1
]}

Hong, CI ^{[1
]}

机构：

[1] Chong Kun Dang Res Inst, New Drug Res Labs, Cheonan 330831, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 03期

关键词：

D O I：

10.1248/cpb.51.276

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of erythrose, ribose, and substituted pyrrolidine containing 2,4-thiazolidinediones were synthesized. Among them, thirteen unsaturated thiazolidinediones, six saturated thiazolidinediones and two unsaturated malonates were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. On the basis of the in vitro activity, 5-{4-[2-(1-benzyl-3,4-bis-benzyloxypyrrolidin-2-yl)ethoxy]benzylidene}thiazolidine-2,4-dione 24b was selected as the candidate for further pharmacological studies.

引用

页码：276 / 285

页数：10

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