Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice

被引:34
作者
Lee, Jong Seok [1 ]
Kim, Kui-Jin [2 ]
Kim, Young-Hyun [1 ]
Kim, Dan-Bi [1 ]
Shin, Gi-Hae [1 ]
Cho, Ju-Hyun [3 ]
Kim, Bong Kyun [3 ]
Lee, Boo-Yong [4 ]
Lee, Ok-Hwan [1 ]
机构
[1] Kangwon Natl Univ, Dept Food Sci & Biotechnol, Chunchon 200701, South Korea
[2] Univ Maryland, Dept Nutr & Food Sci, Coll Agr & Nat Resources, College Pk, MD 20742 USA
[3] Hurum Cent Res Inst, Ochang 363883, South Korea
[4] CHA Univ, Dept Food Sci & Biotechnol, Songnam 463836, South Korea
关键词
obesity; Codonopsis lanceolata; body weight; cholesterol; triglyceride; ANTI-ADIPOGENIC ACTIVITY; CORONARY-HEART-DISEASE; ANIMAL-MODELS; FATTY LIVER; OXIDATIVE STRESS; MOUSE; CELLS; ANTIOXIDANT; POLYPHENOLS; INVOLVEMENT;
D O I
10.3390/nu6114663
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice.
引用
收藏
页码:4663 / 4677
页数:15
相关论文
共 45 条
[1]  
Bais S., 2014, Adv. Biol, V2014, P9, DOI [10.1155/2014/162914, DOI 10.1155/2014/162914]
[2]   Resveratrol improves health and survival of mice on a high-calorie diet [J].
Baur, Joseph A. ;
Pearson, Kevin J. ;
Price, Nathan L. ;
Jamieson, Hamish A. ;
Lerin, Carles ;
Kalra, Avash ;
Prabhu, Vinayakumar V. ;
Allard, Joanne S. ;
Lopez-Lluch, Guillermo ;
Lewis, Kaitlyn ;
Pistell, Paul J. ;
Poosala, Suresh ;
Becker, Kevin G. ;
Boss, Olivier ;
Gwinn, Dana ;
Wang, Mingyi ;
Ramaswamy, Sharan ;
Fishbein, Kenneth W. ;
Spencer, Richard G. ;
Lakatta, Edward G. ;
Le Couteur, David ;
Shaw, Reuben J. ;
Navas, Placido ;
Puigserver, Pere ;
Ingram, Donald K. ;
de Cabo, Rafael ;
Sinclair, David A. .
NATURE, 2006, 444 (7117) :337-342
[3]   Molecular mediators of hepatic steatosis and liver injury [J].
Browning, JD ;
Horton, JD .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (02) :147-152
[4]  
BUSH TL, 1988, CLIN CHEM, V34, pB60
[5]   Acanthopanax senticosus extract prepared from cultured cells decreases adiposity and obesity indices in C57BL/6J mice fed a high fat diet [J].
Cha, YS ;
Rhee, SJ ;
Heo, YR .
JOURNAL OF MEDICINAL FOOD, 2004, 7 (04) :422-429
[6]   Gallic Acid Ameliorated Impaired Glucose and Lipid Homeostasis in High Fat Diet-Induced NAFLD Mice [J].
Chao, Jung ;
Huo, Teh-Ia ;
Cheng, Hao-Yuan ;
Tsai, Jen-Chieh ;
Liao, Jiunn-Wang ;
Lee, Meng-Shiou ;
Qin, Xue-Mei ;
Hsieh, Ming-Tsuen ;
Pao, Li-Heng ;
Peng, Wen-Huang .
PLOS ONE, 2014, 9 (06)
[7]   Protective Effect of Codonopsis lanceolata Root Extract Against Alcoholic Fatty Liver in the Rat [J].
Cho, Keunsook ;
Kim, Seung-Jin ;
Park, Sung-Hee ;
Kim, Sojin ;
Park, Taesun .
JOURNAL OF MEDICINAL FOOD, 2009, 12 (06) :1293-1301
[8]   Antiobesity Effect of Codonopsis lanceolata in High-Calorie/High-Fat-Diet-Induced Obese Rats [J].
Choi, Hye-Kyung ;
Won, Eun-Kyung ;
Jang, Young Pyo ;
Choung, Se-Young .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 2013
[9]   Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics [J].
Collins, S ;
Martin, TL ;
Surwit, RS ;
Robidoux, J .
PHYSIOLOGY & BEHAVIOR, 2004, 81 (02) :243-248
[10]   Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids [J].
D'souza, Anna M. ;
Beaudry, Jacqueline L. ;
Szigiato, Andrei A. ;
Trumble, Stephen J. ;
Snook, Laelie A. ;
Bonen, Arend ;
Giacca, Adria ;
Riddell, Michael C. .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 302 (08) :G850-G863