Is karyotyping couples experiencing recurrent miscarriage worth the cost?

被引：29

作者：

Barber, J. C. K. ^{[1
,2
]}

Cockwell, A. E. ^{[1
]}

Grant, E. ^{[3
]}

Williams, S. ^{[4
]}

Dunn, R. ^{[5
]}

Ogilvie, C. M. ^{[5
]}

机构：

[1] Salisbury Dist Hosp, Salisbury NHS Fdn Trust, Wessex Reg Genet Lab, Salisbury SP2 8BJ, Wilts, England

[2] Salisbury Dist Hosp, Salisbury NHS Fdn Trust, Natl Genet Reference Lab Wessex, Salisbury SP2 8BJ, Wilts, England

[3] Univ London St Georges Hosp, Sch Med, Reg Cytogenet Unit, London SW17 0RE, England

[4] Sheffield Childrens NHS Trust, N Trent Cytogenet Serv, Sheffield, S Yorkshire, England

[5] Guys & St Thomas NHS Fdn Trust, Dept Cytogenet, London, England

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2010年 / 117卷 / 07期

关键词：

Cost effectiveness; karyotyping; policy; prevention; recurrent miscarriage; unbalanced karyotypes; STRUCTURAL CHROMOSOME-ABNORMALITIES;

D O I：

10.1111/j.1471-0528.2010.02566.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Karyotyping couples that have had recurrent miscarriages detects balanced rearrangements in carrier parents who can be offered prenatal cytogenetic analysis to prevent the birth of a subsequent child with an unbalanced rearrangement. In four UK centres, over periods of 5-30 years, balanced rearrangements were found in 406 out of 20 432 parents that had experienced miscarriage (1.9%), but only four unbalanced rearrangements were found after referral for prenatal diagnosis because of a balanced parental translocation ascertained for recurrent miscarriages. At an estimated cost of 3-4 pound million, these data raise doubts about the cost effectiveness of current policies on the routine karyotyping of couples experiencing repeated miscarriages.

引用

页码：885 / 888

页数：4

共 6 条

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