Total Synthesis of (±)-Galanthamine via a C3-Selective Stille Coupling and IMDA Cycloaddition Cascade of 3,5-Dibromo-2-pyrone

被引：78
作者：
Chang, Jay Hyok [1 ]
Kang, Ho-Ung [1 ]
Jung, In-Hak [1 ]
Cho, Cheon-Gyu [1 ]
机构：
[1] Hanyang Univ, Dept Chem, Seoul 133791, South Korea
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
DIELS-ALDER CYCLOADDITIONS; (-)-GALANTHAMINE; (+/-)-CRININE; TANDEM; DRUG;
D O I：
10.1021/ol100617u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new efficient synthetic route to (+/-)-galanthamine was devised by using a tandem C3-selective Stifle coupling-IMDA cascade of 3,5-dibromo-2-pyrone as a key strategy.
引用
收藏
页码：2016 / 2018
页数：3
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