Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury

被引：77

作者：

Deng, Chao ^{[1
,2
,3
]}

Zhao, Lin ^{[4
]}

Yang, Zhi ^{[1
,5
]}

Shang, Jia-jia ^{[1
,5
]}

Wang, Chang-yu ^{[6
]}

Shen, Ming-zhi ^{[7
]}

Jiang, Shuai ^{[1
,5
]}

Li, Tian ^{[1
]}

Di, Wen-cheng ^{[8
]}

Chen, Ying ^{[9
]}

Li, He ^{[1
,5
]}

Cheng, Ye-dong ^{[2
]}

Yang, Yang ^{[1
,5
]}

机构：

[1] Northwest Univ, Xian Hosp 3, Sch Life Sci & Med, Xian Key Lab Cardiovasc & Cerebrovasc Dis, Xian 710021, Peoples R China

[2] Nanjing Univ, Med Sch, Huaian Med Dist Jingling Hosp, Dept Orthopaed, Huaian 213001, Peoples R China

[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiovasc Surg, Xian 710061, Peoples R China

[4] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, Xian 710032, Peoples R China

[5] Northwest Univ, Minist Educ Life Sci, Key Lab Resource Biol & Biotechnol Western China, Xian 710021, Peoples R China

[6] Northwest Univ, Sch Life Sci & Med, Xian Hosp 3, Dept Cardiol, Xian 710021, Peoples R China

[7] Southern Med Univ, Sch Clin Med 2, PLA Gen Hosp, Hainan Hosp, Sanya 572013, Peoples R China

[8] Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Shenzhen 518100, Peoples R China

[9] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Hematol, Xian 710061, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2022年 / 43卷 / 03期

基金：

中国国家自然科学基金;

关键词：

high mobility group box 1; sepsis; LPS; inflammation; Toll-like receptor; ACUTE LUNG INJURY; BOX; PROTEIN; ENDOPLASMIC-RETICULUM STRESS; ACUTE KIDNEY INJURY; PROINFLAMMATORY CYTOKINE; MITOCHONDRIAL DYSFUNCTION; DENDRITIC CELLS; ALARMIN HMGB1; UP-REGULATION; DNA;

D O I：

10.1038/s41401-021-00676-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is present in almost all cells and regulates the activity of innate immune responses in both intracellular and extracellular settings. Current evidence suggests that HMGB1 plays a pivotal role in human pathological and pathophysiological processes such as the inflammatory response, immune reactions, cell migration, aging, and cell death. Sepsis is a systemic inflammatory response syndrome (SIRS) that occurs in hosts in response to microbial infections with a proven or suspected infectious etiology and is the leading cause of death in intensive care units worldwide, particularly in the aging population. Dysregulated systemic inflammation is a classic characteristic of sepsis, and suppression of HMGB1 may ameliorate inflammation and improve patient outcomes. Here, we focus on the latest breakthroughs regarding the roles of HMGB1 in sepsis and sepsis-related organ injury, the ways by which HMGB1 are released, and the signaling pathways and therapeutics associated with HMGB1. This review highlights recent advances related to HMGB1: the regulation of HMBG1 might be helpful for both basic research and drug development for the treatment of sepsis and sepsis-related organ injury.

引用

页码：520 / 528

页数：9

共 120 条

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