Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy

被引：883
作者：
Saito, Shigeru [1 ]
Nakashima, Akitoshi [1 ]
Shima, Tomoko [1 ]
Ito, Mika [1 ]
机构：
[1] Toyama Univ, Dept Obstet & Gynecol, Toyama 9300194, Japan
来源：
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2010年 / 63卷 / 06期
关键词：
Abortion; cytokine network; implantation; preterm labor; reproduction; FETAL-MATERNAL INTERFACE; NATURAL-KILLER-CELLS; PERIPHERAL-BLOOD; SPONTANEOUS-ABORTION; FETOMATERNAL INTERFACE; PLACENTAL DEVELOPMENT; HEALTHY PREGNANCY; DECIDUAL CD4(+); DENDRITIC CELLS; PREECLAMPSIA;
D O I：
10.1111/j.1600-0897.2010.00852.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-beta and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.
引用
收藏
页码：601 / 610
页数：10
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