Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors

被引：391

作者：

Grosser, Rachel ^{[1
]}

Cherkassky, Leonid ^{[2
]}

Chintala, Navin ^{[1
]}

Adusumilli, Prasad S. ^{[1
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Surg, Thorac Serv, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc, Dept Surg, Surg Oncol Serv, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10065 USA

来源：

CANCER CELL | 2019年 / 36卷 / 05期

关键词：

PD-1; BLOCKADE; ANTITUMOR-ACTIVITY; CANCER-IMMUNOTHERAPY; ESTABLISHED TUMORS; ANTI-PD-1; ANTIBODY; CLINICAL ACTIVITY; HOST IMMUNITY; ANTIGEN; RECEPTOR; EXPRESSION;

D O I：

10.1016/j.ccell.2019.09.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Checkpoint blockade (CPB) therapy can elicit durable clinical responses by reactivating an exhausted immune response. However, response rates remain limited, likely secondary to a lack of a tumor-reactive immune infiltrate. Chimeric antigen receptor (CAR) T cells may provide the necessary tumor-targeting immune infiltrate and a highly specific antitumor immune response. This can be further amplified by the addition of CPB agents, which serve to counteract the immune inhibitory environment undermining optimal CAR T cell efficacy. Herein, we review preclinical and clinical combination therapy with CAR T cells and CPB agents, with a focus on solid tumor malignancies.

引用

页码：471 / 482

页数：12

共 123 条

[1] A phase I clinical trial of malignant pleural disease treated with regionally delivered autologous mesothelin-targeted CAR T cells: Safety and efficacy [J].

Adusumilli, Prasad S. ;

Zauderer, Marjorie G. ;

Rusch, Valerie W. ;

O'Cearbhaill, Roisin E. ;

Zhu, Amy ;

Ngai, Daniel A. ;

McGee, Erin ;

Chintala, Navin K. ;

Messinger, John C. ;

Vincent, Alain ;

Halton, Elizabeth F. ;

Diamonte, Claudia ;

Pineda, John ;

Modi, Shanu ;

Solomon, Stephen B. ;

Jones, David R. ;

Brentjens, Renier J. ;

Riviere, Isabelle ;

Sadelain, Michel .

CANCER RESEARCH, 2019, 79 (13)

[2] Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity [J].

Adusumilli, Prasad S. ;

Cherkassky, Leonid ;

Villena-Vargas, Jonathan ;

Colovos, Christos ;

Servais, Elliot ;

Plotkin, Jason ;

Jones, David R. ;

Sadelain, Michel .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (261)

[3] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[4] Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade [J].

Ariyan, Charlotte E. ;

Brady, Mary Sue ;

Siegelbaum, Robert H. ;

Hu, Jian ;

Bello, Danielle M. ;

Rand, Jamie ;

Fisher, Charles ;

Lefkowitz, Robert A. ;

Panageas, Kathleen S. ;

Pulitzer, Melissa ;

Vignali, Marissa ;

Emerson, Ryan ;

Tipton, Christopher ;

Robins, Harlan ;

Merghoub, Taha ;

Yuan, Jianda ;

Jungbluth, Achim ;

Blando, Jorge ;

Sharma, Padmanee ;

Rudensky, Alexander Y. ;

Wolchok, Jedd D. ;

Allison, James P. .

CANCER IMMUNOLOGY RESEARCH, 2018, 6 (02) :189-200

[5] Tumor-Infiltrating Lymphocyte Grade Is an Independent Predictor of Sentinel Lymph Node Status and Survival in Patients With Cutaneous Melanoma [J].

Azimi, Farhad ;

Scolyer, Richard A. ;

Rumcheva, Pavlina ;

Moncrieff, Marc ;

Murali, Rajmohan ;

McCarthy, Stanley W. ;

Saw, Robyn P. ;

Thompson, John F. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (21) :2678-2683

[6] Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer [J].

Balachandran, Vinod P. ;

Luksza, Marta ;

Zhao, Julia N. ;

Makarov, Vladimir ;

Moral, John Alec ;

Remark, Romain ;

Herbst, Brian ;

Askan, Gokce ;

Bhanot, Umesh ;

Senbabaoglu, Yasin ;

Wells, Daniel K. ;

Cary, Charles Ian Ormsby ;

Grbovic-Huezo, Olivera ;

Attiyeh, Marc ;

Medina, Benjamin ;

Zhang, Jennifer ;

Loo, Jennifer ;

Saglimbeni, Joseph ;

Abu-Akeel, Mohsen ;

Zappasodi, Roberta ;

Riaz, Nadeem ;

Smoragiewicz, Martin ;

Kelley, Z. Larkin ;

Basturk, Olca ;

Goenen, Mithat ;

Levine, Arnold J. ;

Allen, Peter J. ;

Fearon, Douglas T. ;

Merad, Miriam ;

Gnjatic, Sacha ;

Iacobuzio-Donahue, Christine A. ;

Wolchok, Jedd D. ;

DeMatteo, Ronald P. ;

Chan, Timothy A. ;

Greenbaum, Benjamin D. ;

Merghoub, Taha ;

Leach, Steven D. .

NATURE, 2017, 551 (7681) :512-+

[7] Restoring function in exhausted CD8 T cells during chronic viral infection [J].

Barber, DL ;

Wherry, EJ ;

Masopust, D ;

Zhu, BG ;

Allison, JP ;

Sharpe, AH ;

Freeman, GJ ;

Ahmed, R .

NATURE, 2006, 439 (7077) :682-687

[8] Pembrolizumab for Platinum- and Cetuximab-Refractory Head and Neck Cancer: Results From a Single-Arm, Phase II Study [J].

Bauml, Joshua ;

Seiwert, Tanguy Y. ;

Pfister, David G. ;

Worden, Francis ;

Liu, Stephen V. ;

Gilbert, Jill ;

Saba, Nabil F. ;

Weiss, Jared ;

Wirth, Lori ;

Sukari, Ammar ;

Kang, Hyunseok ;

Gibson, Michael K. ;

Massarelli, Erminia ;

Powell, Steven ;

Meister, Amy ;

Shu, Xinxin ;

Cheng, Jonathan D. ;

Haddad, Robert .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (14) :1542-+

[9] The "cancer immunogram" [J].

Blank, Christian U. ;

Haanen, John B. ;

Ribas, Antoni ;

Schumacher, Ton N. .

SCIENCE, 2016, 352 (6286) :658-660

[10] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

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