The scaffold microenvironment for stem cell based bone tissue engineering

被引：130
作者：
Hao, Zhichao [1 ]
Song, Zhenhua [2 ]
Huang, Jun [2 ]
Huang, Keqing [2 ]
Panetta, Amanda [3 ]
Gu, Zhipeng [2 ]
Wu, Jun [2 ,4 ]
机构：
[1] Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou 510055, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Engn, Key Lab Sensing Technol & Biomed Instrument Guang, Guangzhou 510006, Guangdong, Peoples R China
[3] Univ Windsor, Windsor, ON, Canada
[4] Sun Yat Sen Univ, Minist Educ, Key Lab Polymer Composite & Funct Mat, Guangzhou 510275, Guangdong, Peoples R China
来源：
BIOMATERIALS SCIENCE | 2017年 / 5卷 / 08期
基金：
中国国家自然科学基金;
关键词：
IN-VITRO; REGENERATIVE MEDICINE; DESIGNING MATERIALS; MATRIX INTERACTIONS; NICHE; PEPTIDE; MARROW; BIOMATERIALS; HYDROGELS; FATE;
D O I：
10.1039/c7bm00146k
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Bone tissue engineering uses the principles and methods of engineering and life sciences to study bone structure, function and growth mechanism for the purposes of repairing, maintaining and improving damaged bone tissue. Scaffolds not only provide structural support for stem cells in cell adhesion and proliferation and bone formation, but also serve as a microenvironment for guiding stem cell differentiation and tissue regeneration and for controlling tissue structure. This review presents the research status of the scaffold microenvironment for bone-related stem cells based on bone tissue engineering. Scaffold materials and the stem cell microenvironment are described in this review, and the existing shortcomings are also simply mentioned.
引用
收藏
页码：1382 / 1392
页数：11
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