Aurora kinases A and B and familial breast cancer risk

被引：47

作者：

Tchatchou, Sandrine ^{[1
]}

Wirtenberger, Michael

Hemminki, Kari

Sutter, Christian

Meindl, Alfons

Wappenschmidt, Barbara

Kiechle, Marion

Bugert, Peter

Schmutzler, Rita K.

Bartram, Claus R.

Burwinkel, Barbara

机构：

[1] German Canc Res Ctr, Div Mol Genet Epidemiol, D-6900 Heidelberg, Germany

[2] Karolinska Inst, Novum, Dept Biosci, Huddinge, Sweden

[3] Heidelberg Univ, Inst Human Genet, Heidelberg, Germany

[4] Tech Univ Munich, Klinikum Rechts Isar, Dept Obstet & Gynaecol, D-8000 Munich, Germany

[5] Univ Cologne, Div Mol Gynaeco Oncol, Dept Obstet & Gynaecol, Ctr Clin, Cologne, Germany

[6] Univ Hosp Cologne, Ctr Mol Med Cologne, Cologne, Germany

[7] Heidelberg Univ, Fac Clin Med, Inst Transfus Med & Immunol, Red Cross Blood Serv Baden Wurttemberg Hessia, D-6800 Mannheim, Germany

[8] Helmholtz Univ, Grp Mol Epidemiol, German Canc Res Ctr, Heidelberg, Germany

来源：

CANCER LETTERS | 2007年 / 247卷 / 02期

关键词：

breast cancer; case-control study; aurora kinases; polymorphism;

D O I：

10.1016/j.canlet.2006.05.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aurora genes play a crucial role in tumourigenesis and are overexpressed in many kinds of cancers. We investigated whether coding variants within the Aurora genes are associated with familial breast cancer risk. While AURKA Phe31Ile (1712T > A) and AURKB Thr298Met (893G > A) showed no association, the synonymous AURKB Ser295Ser (885A > G) polymorphism resulted in an increased breast cancer risk for carriers of the homozygous 885G genotype (OR = 1.45, 95% CI = 1.05-2.0, P = 0.02). Due to the impact of aurora kinases in the loss of chromosomal integrity during carcinogenesis, this variant may also influence the therapy outcome in breast cancer. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：266 / 272

页数：7

共 55 条

[1] Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells
Adams, RR
Eckley, DM
Vagnarelli, P
Wheatley, SP
Gerloff, DL
Mackay, AM
Svingen, PA
Kaufmann, SH
Earnshaw, WC
[J]. CHROMOSOMA, 2001, 110 (02) : 65 - 74
[2] Mitotic mechanics: the auroras come into view
Andrews, PD
Knatko, E
Moore, WJ
Swedlow, JR
[J]. CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (06) : 672 - 683
[3] Haploview: analysis and visualization of LD and haplotype maps
Barrett, JC
Fry, B
Maller, J
Daly, MJ
[J]. BIOINFORMATICS, 2005, 21 (02) : 263 - 265
[4] A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
Bischoff, JR
Anderson, L
Zhu, YF
Mossie, K
Ng, L
Souza, B
Schryver, B
Flanagan, P
Clairvoyant, F
Ginther, C
Chan, CSM
Novotny, M
Slamon, DJ
Plowman, GD
[J]. EMBO JOURNAL, 1998, 17 (11) : 3052 - 3065
[5] Evolutionary relationships of Aurora kinases: Implications for model organism studies and the development of anti-cancer drugs
Brown, JR
Koretke, KK
Birkeland, ML
Sanseau, P
Patrick, DR
[J]. BMC EVOLUTIONARY BIOLOGY, 2004, 4 (1)
[6] Familial cancer associated with a polymorphism in ARLTS1
Calin, GA
Trapasso, F
Shimizu, M
Dumitru, CD
Yendamuri, S
Godwin, AK
Ferracin, M
Bernardi, G
Chatterjee, D
Baldassarre, G
Rattan, S
Alder, H
Mabuchi, H
Shiraishi, T
Hansen, LL
Overgaard, J
Herlea, V
Mauro, FR
Dighiero, G
Movsas, B
Rassenti, L
Kipps, T
Baffa, R
Fusco, A
Mori, M
Russo, G
Liu, CG
Neuberg, D
Bullrich, F
Negrini, M
Croce, CM
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (16) : 1667 - 1676
[7] The cellular geography of aurora kinases
Carmena, M
Earnshaw, WC
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (11) : 842 - 854
[8] APC/Fizzy-Related targets Aurora-A kinase for proteolysis
Castro, A
Arlot-Bonnemains, Y
Vigneron, S
Labbé, JC
Prigent, C
Lorca, T
[J]. EMBO REPORTS, 2002, 3 (05) : 457 - 462
[9] Chenevix-Trench G, 2002, JNCI-J NATL CANCER I, V94, P205, DOI 10.1093/jnci/94.3.205
[10] DiCioccio RA, 2004, CANCER EPIDEM BIOMAR, V13, P1589

← 1 2 3 4 5 6 →