A case report of a thymic neuroblastoma associated with syndrome of inappropriate secretion of antidiuretic hormone: Ten-year follow-up results after surgical treatment

INTRODUCTION: Thymic neuroblastoma with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in adults is an extremely rare and malignant neoplasm. Although the tumor is known to grow rapidly and have a poor prognosis, its etiology is still uncertain. In 2009, we described a case of thymic neuroblastoma with SIADH. We report here the clinical course over the last 10 years. PRESENTATION OF CASE: A 70-year-old Japanese male with a history of thymic neuroblastoma with SIADH was regularly followed up on an out-patient basis after complete surgical resection for more than 10 years. He remains free of the disease and asymptomatic. DISCUSSION AND CONCLUSION: Complete surgical removal is considered as one of the treatment options for this tumor if clearly separated from the surrounding tissue with no invasion. (C) 2019 The Author. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.