Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide

被引：14
作者：
Wahyudiono [1 ,2 ]
He, Jiayang [1 ]
Hu, Xin [1 ]
Machmudah, Siti [3 ]
Yasuda, Keiji [4 ]
Takami, Seiichi [1 ]
Kanda, Hideki [1 ]
Goto, Motonobu [1 ,5 ]
机构：
[1] Nagoya Univ, Dept Mat Proc Engn, Nagoya, Aichi 4648603, Japan
[2] Tohoku Univ, New Ind Creat Hatchery Ctr, Aoba Ku, 6-6-10 Aoba, Sendai, Miyagi 9808579, Japan
[3] Inst Teknol Sepuluh Nopember, Dept Chem Engn, Surabaya 60111, Indonesia
[4] Nagoya Univ, Dept Chem Syst Engn, Nagoya, Aichi 4648603, Japan
[5] Super Crit Technol Ctr Co Ltd, Kuwana 5110838, Japan
来源：
FOODS | 2022年 / 11卷 / 10期
关键词：
supercritical; curcumin; encapsulation; liposome; phospholipid; PHOSPHOLIPIDS; ENCAPSULATION; ANTIOXIDANT; EXTRACTION; STABILITY;
D O I：
10.3390/foods11101469
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO2)- ultrasound environment system. The experiments were performed at temperatures of 40-70 degrees C and pressures of 10-25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids.
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页数：16
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