The impact of L-citrulline supplementation on glucose homeostasis, lipid profile, and some inflammatory factors in overweight and obese patients with type 2 diabetes: A double-blind randomized placebo-controlled trial

被引:18
作者
Azizi, Samaneh [1 ]
Mahdavi, Reza [2 ]
Mobasseri, Majid [3 ]
Aliasgharzadeh, Soghra [1 ]
Abbaszadeh, Fatemeh [1 ]
Ebrahimi-Mameghani, Mehrangiz [2 ]
机构
[1] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Student Res Comm, Tabriz, Iran
[2] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Dept Biochem & Diet Therapy, Nutr Res Ctr, Attar Neyshabouri Av,Golgasht St, Tabriz, East Azerbaijan, Iran
[3] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran
关键词
glucose homeostasis; inflammation; L‐ citrulline; lipid profile; type; 2; diabetes; HEART-FAILURE PATIENTS; FATTY LIVER-DISEASE; ORAL L-CITRULLINE; INSULIN-RESISTANCE; L-ARGININE; PERITONEAL-MACROPHAGES; VENTRICULAR-FUNCTION; PLASMA; MARKERS; VASODILATION;
D O I
10.1002/ptr.6997
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This study investigated the impact of L-citrulline on glucose homeostasis, lipid profile, and inflammatory factors in overweight and obese patients with type 2 diabetes (T2D). In total, 54 participants with T2D were assigned to L-citrulline (3 g/day L-citrulline) or placebo groups and tested for 8 weeks. Serum levels of insulin, fasting glucose, hemoglobin A1c (HbA1c), lipid profile, tumor necrosis factor-alpha (TNF-alpha), high-sensitivity C-reactive protein (hs-CRP), and L-citrulline were measured pre- and post-intervention. Totally, 45 patients were enrolled in the research. L-citrulline supplementation decreased serum levels of insulin (p = .025), glucose (p = .032), HbA1c (p = .001), HOMA-IR (p = .037), TNF-alpha (p = .036), and hs-CRP (p = .027) significantly. At the end of the study, despite the significant decrease in serum levels of triglyceride (p = .027) and the increase in high-density lipoprotein cholesterol levels (p < .001) in the L-citrulline group, no significant differences were found for these parameters between the groups. Moreover, no significant inter- and intra-group changes were observed for dietary intakes, anthropometric indices, total and low-density lipoprotein cholesterol levels (p > .05). In conclusion, L-citrulline supplementation might improve glucose homeostasis, some lipid factors and inflammatory markers in overweight and obese patients with T2D.
引用
收藏
页码:3157 / 3166
页数:10
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