Effects of CPAP on Testosterone Levels in Patients With Obstructive Sleep Apnea: A Meta-Analysis Study

被引：24
作者：
Cignarelli, Angelo [1 ]
Castellana, Marco [1 ]
Castellana, Giorgio [2 ]
Francesco, Sebastio [1 ]
Brescia, Francesco [1 ]
Natalicchio, Annalisa [1 ]
Garruti, Gabriella [1 ]
Laviola, Luigi [1 ]
Resta, Onofrio [3 ]
Giorgino, Francesco [1 ]
机构：
[1] Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Sect Internal Med Endocrinol Androl & Metab Dis, Bari, Italy
[2] IRCCS Cassano Delle Murge, ICS Maugeri Spa SB, Pulm Div, Cassano Delle Murge, Italy
[3] Univ Bari Aldo Moro, Inst Resp Dis, Bari, Italy
来源：
FRONTIERS IN ENDOCRINOLOGY | 2019年 / 10卷
关键词：
obstructive sleep apnea; continuous positive airway pressure; testosterone; hypogonadism-hypotestosteronemia-androgen deficiency; obesity complications; POSITIVE AIRWAY PRESSURE; BODY-MASS INDEX; ERECTILE DYSFUNCTION; SEXUAL FUNCTION; ORAL-APPLIANCE; OBESE MEN; THERAPY; HORMONE; ADHERENCE; QUALITY;
D O I：
10.3389/fendo.2019.00551
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Obstructive sleep apnea (OSA) represents a frequent complication among patients with obesity and has been associated with neuroendocrine changes, including hypogonadism. Objective: We conducted a systematic review and meta-analysis to evaluate the effects of continuous positive airway pressure (CPAP) on testosterone and gonadotropins in male patients with OSA. Methods: The review was registered on PROSPERO (CRD42018103164). PubMed, Scopus, CENTRAL, and Clinicaltrials.gov were searched until June 2018. Studies reporting the effect of CPAP on total testosterone, free testosterone, sexual hormone binding globulin (SHBG), follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were included. A subgroup analysis on hypogonadal vs. eugonadal status at baseline was performed. Results: Out of 129 retrieved papers, 10 prospective cohort and 2 randomized controlled studies were included in the review. Three hundred eighty-eight patients were included. CPAP use was not associated with a significant change in total testosterone levels [mean difference 1.08, 95% confidence interval (CI) -0.48 to 2.64] or other outcomes. The subgroup analysis confirmed the overall results. Conclusions: The present review does not support the hypothesis of a direct interaction between OSA and testosterone. Strategies other than CPAP should therefore be considered in managing hypogonadism in patients with OSA.
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页数：9
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