Catalyst-Free Visible-Light-Mediated Iodoamination of Olefins and Synthetic Applications

被引：36
|
作者：
Engl, Sebastian [1 ]
Reiser, Oliver [1 ]
机构：
[1] Univ Regensburg, Inst Organ Chem, D-93053 Regensburg, Germany
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 14期
关键词：
ALKENES; NITROGEN; AMINOBROMINATION; AMINES; AMINOHALOGENATION; AMINOCHLORINATION;
D O I：
10.1021/acs.orglett.1c02035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report a catalyst- and metal-free visible-light-mediated protocol enabling the iodoamination of miscellaneous olefins. This protocol is characterized by high yields under environmentally benign reaction conditions utilizing commercially available substrates and a green and biodegradable solvent. Furthermore, the protocol allows for late-stage functionalization of bioactive molecules and can be scaled to gram quantities of product, which offers manifold possibilities for further transformations, including morpholine, piperidine, pyrrolidine, and aziridine synthesis.
引用
收藏
页码：5581 / 5586
页数：6
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