Weak biofilm formation among carbapenem-resistant Klebsiella pneumoniae

被引：27

作者：

Cusumano, Jaclyn A. ^{[1
,2
]}

Caffrey, Aisling R. ^{[1
,2
,3
]}

Daffinee, Kathryn E. ^{[1
]}

Luther, Megan K. ^{[1
,2
,3
]}

Lopes, Vrishali ^{[1
]}

LaPlante, Kerry L. ^{[1
,2
,3
,4
]}

机构：

[1] Providence Vet Affairs Med Ctr, Infect Dis Res Program, Providence, RI 02908 USA

[2] Univ Rhode Isl, Coll Pharm, Kingston, RI 02881 USA

[3] Providence Vet Affairs Med Ctr, Ctr Innovat Long Term Support Serv, Providence, RI 02908 USA

[4] Brown Univ, Div Infect Dis, Warren Alpert Med Sch, Providence, RI 02912 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2019年 / 95卷 / 04期

关键词：

Klebsiella pneumoniae; Biofilm; Carbapenem resistance; STRAINS; PLATES;

D O I：

10.1016/j.diagmicrobio.2019.114877

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Biofilm formation of multidrug and extensively drug resistant Klebsiella pneumoniae isolates is poorly understood. We investigated 139 diverse clinical K. pneumoniae isolates that possess various resistance patterns to evaluate the relationship between biofilm formation and resistance. Antimicrobial resistance was compared among a diverse collection of weak versus strong biofilm-forming K. pneumoniae, and predictors of strong biofilm formation were identified. Multi-drug resistant isolates were more common among weak (97.9%) versus strong biofilm formers (76%; P = 0.002). Carbapenem-resistant K. pneumoniae were 91% less likely to form strong biofilm (odds ratio 0.09; 95% confidence interval 0.02-0.33). The statistically significant inverse relationship between biofilm formation and antibiotic resistance suggests that virulence may be a trade-off for survival. Published by Elsevier Inc.

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页数：5

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