Genetic abnormalities of cell proliferation, invasion and metastasis, with special reference to gynaecological cancers

被引：1

作者：

Sherbet, GV

Patil, D

机构：

[1] Newcastle Univ, Sch Elect Elect & Comp Engn, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Inst Mol Med, Huntington Beach, CA USA

[3] James Paget Healthcare NHS Trust, Great Yarmouth, England

来源：

ANTICANCER RESEARCH | 2003年 / 23卷 / 2B期

关键词：

cell cycle control; cell proliferation; cyclins; c-erbB2; growth factors; growth factor receptors; gynaecological cancers; human papilloma virus; invasion; metastasis; oncogenes; p53; Rb; suppressor genes; tumour heterogeneity;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review focuses on molocular events with the progression of gnaecological malignancies. The association of genetic abnormalities in cell cycle regulator genes, tumor suppressor genes and gene coding for growth factor receptors, with the progression of gynaecological cancers is reviewed. The possibility that some of these genes, cell cycle regulator genes in particular, could be co-operating with human papilloma virus genes in the induction and progression of gnaecological cancers is also discussed. The clinical effectiveness and reliability of these genes as markers of cancer progression and predictors of disease prognosis have been evaluated.

引用

页码：1357 / 1371

页数：15

共 145 条

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